Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4095615..4096234 Replicon chromosome
Accession NZ_CP084859
Organism Klebsiella pneumoniae strain SB1139

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM11_RS20245 Protein ID WP_002892050.1
Coordinates 4096016..4096234 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM11_RS20240 Protein ID WP_002892066.1
Coordinates 4095615..4095989 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM11_RS20230 (4090767) 4090767..4091960 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGM11_RS20235 (4091983) 4091983..4095129 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LGM11_RS20240 (4095615) 4095615..4095989 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM11_RS20245 (4096016) 4096016..4096234 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM11_RS20250 (4096397) 4096397..4096963 + 567 WP_002892030.1 maltose O-acetyltransferase -
LGM11_RS20255 (4096935) 4096935..4097075 - 141 WP_004147370.1 hypothetical protein -
LGM11_RS20260 (4097096) 4097096..4097566 + 471 WP_002892026.1 YlaC family protein -
LGM11_RS20265 (4097541) 4097541..4098992 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LGM11_RS20270 (4099093) 4099093..4099791 + 699 WP_002892021.1 GNAT family protein -
LGM11_RS20275 (4099788) 4099788..4099928 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM11_RS20280 (4099928) 4099928..4100191 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219607 WP_002892050.1 NZ_CP084859:4096016-4096234 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219607 NZ_CP116557:c2616754-2616413 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACTCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219607 WP_002892066.1 NZ_CP084859:4095615-4095989 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219607 NZ_CP116557:c2616984-2616754 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References