Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2711282..2712870 Replicon chromosome
Accession NZ_CP084859
Organism Klebsiella pneumoniae strain SB1139

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag LGM11_RS13365 Protein ID WP_004190166.1
Coordinates 2711282..2712604 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LGM11_RS13370 Protein ID WP_002904790.1
Coordinates 2712604..2712870 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM11_RS13350 (2706338) 2706338..2708839 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
LGM11_RS13355 (2708827) 2708827..2709831 + 1005 WP_004190163.1 fimbrial protein -
LGM11_RS13360 (2709973) 2709973..2711265 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LGM11_RS13365 (2711282) 2711282..2712604 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
LGM11_RS13370 (2712604) 2712604..2712870 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LGM11_RS13375 (2713135) 2713135..2713461 - 327 WP_004143476.1 hydroxyisourate hydrolase -
LGM11_RS13380 (2713458) 2713458..2713958 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LGM11_RS13385 (2713936) 2713936..2715315 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
LGM11_RS13390 (2715661) 2715661..2716815 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LGM11_RS13395 (2716796) 2716796..2717719 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T219605 WP_004190166.1 NZ_CP084859:c2712604-2711282 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T219605 NZ_CP116557:c2543493-2543389 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTTAAATT
GCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT219605 WP_002904790.1 NZ_CP084859:c2712870-2712604 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT219605 NZ_CP116557:2543269-2543456 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTAACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References