Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 894799..895456 Replicon chromosome
Accession NZ_CP084859
Organism Klebsiella pneumoniae strain SB1139

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM11_RS04550 Protein ID WP_002916310.1
Coordinates 895046..895456 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM11_RS04545 Protein ID WP_002916312.1
Coordinates 894799..895065 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM11_RS04520 (889955) 889955..891388 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LGM11_RS04525 (891507) 891507..892235 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGM11_RS04530 (892285) 892285..892596 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LGM11_RS04535 (892760) 892760..893419 + 660 WP_002916317.1 hemolysin III family protein -
LGM11_RS04540 (893570) 893570..894553 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LGM11_RS04545 (894799) 894799..895065 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM11_RS04550 (895046) 895046..895456 + 411 WP_002916310.1 protein YgfX Toxin
LGM11_RS04555 (895463) 895463..895984 - 522 WP_002916308.1 flavodoxin FldB -
LGM11_RS04560 (896085) 896085..896981 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM11_RS04565 (897004) 897004..897717 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM11_RS04570 (897723) 897723..899456 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219596 WP_002916310.1 NZ_CP084859:895046-895456 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219596 NZ_CP116555:c312617-312522 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGCTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219596 WP_002916312.1 NZ_CP084859:894799-895065 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219596 NZ_CP116555:312423-312487 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGCAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References