Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807906..808563 Replicon chromosome
Accession NZ_CP084856
Organism Klebsiella pneumoniae strain SB1170

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM12_RS03975 Protein ID WP_002916310.1
Coordinates 808153..808563 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM12_RS03970 Protein ID WP_002916312.1
Coordinates 807906..808172 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM12_RS03945 (803062) 803062..804495 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
LGM12_RS03950 (804614) 804614..805342 - 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
LGM12_RS03955 (805392) 805392..805703 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGM12_RS03960 (805867) 805867..806526 + 660 WP_002916317.1 hemolysin III family protein -
LGM12_RS03965 (806677) 806677..807660 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LGM12_RS03970 (807906) 807906..808172 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM12_RS03975 (808153) 808153..808563 + 411 WP_002916310.1 protein YgfX Toxin
LGM12_RS03980 (808570) 808570..809091 - 522 WP_002916308.1 flavodoxin FldB -
LGM12_RS03985 (809192) 809192..810088 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM12_RS03990 (810111) 810111..810824 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM12_RS03995 (810830) 810830..812563 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219576 WP_002916310.1 NZ_CP084856:808153-808563 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219576 NZ_CP116537:c123135-122863 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219576 WP_002916312.1 NZ_CP084856:807906-808172 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219576 NZ_CP116537:c123398-123135 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References