Detailed information of TA system TA021957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 6626..7100
• Replicon: plasmid pSbal02
• Accession: NC_009036
• Organism: Shewanella baltica OS155

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: A0A8F3ILQ2
• Locus tag: SBAL_RS23170
• Protein ID: WP_011839957.1
• Coordinates: 6626..6892 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A8F3IL86
• Locus tag: SBAL_RS23175
• Protein ID: WP_011839958.1
• Coordinates: 6876..7100 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL_RS23145	3498..3842	-	345	WP_011839953.1	IS4 family transposase	-
SBAL_RS23150	3891..4208	-	318	WP_011839954.1	recombination regulator RecX	-
SBAL_RS23155	4205..5590	-	1386	WP_011839955.1	hypothetical protein	-
SBAL_RS23165	6244..6633	-	390	WP_011839956.1	hypothetical protein	-
SBAL_RS23170	6626..6892	-	267	WP_011839957.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SBAL_RS23175	6876..7100	-	225	WP_011839958.1	TraY domain-containing protein	Antitoxin
SBAL_RS24230	7178..7405	+	228	Protein_7	IS30 family transposase	-
SBAL_RS23185	7621..7812	+	192	WP_014620453.1	hypothetical protein	-
SBAL_RS24630	8141..8338	-	198	WP_014620454.1	hypothetical protein	-
SBAL_RS23195	8335..8961	-	627	WP_011839960.1	hypothetical protein	-
SBAL_RS24235	9513..9881	-	369	WP_011839961.1	hypothetical protein	-
SBAL_RS23200	9909..11213	+	1305	WP_011839962.1	RNA-directed DNA polymerase	-
SBAL_RS23205	11514..11849	-	336	WP_190272054.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..74000	74000

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Relaxosome protein TraY (4-45)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10355.11 Da
• Isoelectric Point: 9.7697

>T21957 WP_011839957.1 NC_009036:c6892-6626 [Shewanella baltica OS155]
MAWTIDYSERALKSLKKMDKQNAKRILDFLEQRIAILDDPRTSGKPLKGDLGIFWRYRVGDYRVLCEIQDSKLVILTALI
GHRKEIYE

Nucleotide

• Length: 267 bp

>T21957 NC_009036:c6892-6626 [Shewanella baltica OS155]
TTGGCTTGGACAATTGATTACTCAGAACGAGCGCTAAAATCACTAAAAAAAATGGATAAGCAGAACGCTAAACGCATTCT
GGATTTTTTGGAACAGCGCATAGCGATATTGGACGACCCGAGAACGTCAGGAAAGCCCCTGAAGGGGGATTTGGGTATTT
TTTGGCGTTATCGAGTCGGTGACTATCGAGTGCTTTGTGAAATTCAAGATAGCAAATTAGTCATTCTGACTGCTTTGATA
GGGCACAGGAAAGAGATCTATGAGTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8303.30 Da
• Isoelectric Point: 4.4079

>AT21957 WP_011839958.1 NC_009036:c7100-6876 [Shewanella baltica OS155]
MLAIRLPDDIETRLAALADQTGRTKTFYAREAILTHLEDLEDYYLAAQIVSDIRKGAEKTYSSEDVRASLGLDN

Nucleotide

• Length: 225 bp

>AT21957 NC_009036:c7100-6876 [Shewanella baltica OS155]
ATGTTAGCAATACGGTTACCTGATGATATTGAAACCCGTCTGGCTGCTTTGGCAGATCAAACCGGTAGAACAAAAACCTT
TTACGCCAGAGAAGCTATTTTGACTCATTTAGAGGATCTGGAGGATTACTATCTTGCGGCTCAGATTGTCTCTGATATTC
GTAAAGGGGCTGAAAAAACCTACAGTAGCGAAGATGTGAGGGCGTCTCTTGGCTTGGACAATTGA