Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4082687..4083306 Replicon chromosome
Accession NZ_CP084852
Organism Klebsiella pneumoniae strain SB2390

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM13_RS19945 Protein ID WP_002892050.1
Coordinates 4083088..4083306 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM13_RS19940 Protein ID WP_002892066.1
Coordinates 4082687..4083061 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM13_RS19930 (4077839) 4077839..4079032 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGM13_RS19935 (4079055) 4079055..4082201 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LGM13_RS19940 (4082687) 4082687..4083061 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM13_RS19945 (4083088) 4083088..4083306 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM13_RS19950 (4083465) 4083465..4084031 + 567 WP_002892030.1 maltose O-acetyltransferase -
LGM13_RS19955 (4084003) 4084003..4084143 - 141 WP_004147370.1 hypothetical protein -
LGM13_RS19960 (4084164) 4084164..4084634 + 471 WP_002892026.1 YlaC family protein -
LGM13_RS19965 (4084609) 4084609..4086060 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LGM13_RS19970 (4086161) 4086161..4086859 + 699 WP_004178762.1 GNAT family protein -
LGM13_RS19975 (4086856) 4086856..4086996 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM13_RS19980 (4086996) 4086996..4087259 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219568 WP_002892050.1 NZ_CP084852:4083088-4083306 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219568 NZ_CP116525:28799-29149 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219568 WP_002892066.1 NZ_CP084852:4082687-4083061 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219568 NZ_CP116525:28542-28805 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References