Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1856459..1857114 Replicon chromosome
Accession NC_008836
Organism Burkholderia mallei NCTC 10229

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag BMA10229_RS18090 Protein ID WP_004199884.1
Coordinates 1856818..1857114 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BMA10229_RS18085 Protein ID WP_004202809.1
Coordinates 1856459..1856815 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMA10229_RS18055 1852591..1853349 + 759 WP_004199892.1 cytochrome c1 -
BMA10229_RS18060 1853442..1854053 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
BMA10229_RS18065 1854123..1854644 + 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
BMA10229_RS18075 1854866..1855363 + 498 WP_004199888.1 terminase -
BMA10229_RS18080 1855360..1856415 + 1056 WP_004199886.1 phage portal protein -
BMA10229_RS18085 1856459..1856815 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BMA10229_RS18090 1856818..1857114 - 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMA10229_RS18100 1857922..1859042 + 1121 WP_096325434.1 IS3 family transposase -
BMA10229_RS31980 1859070..1859207 - 138 WP_004202832.1 hypothetical protein -
BMA10229_RS18105 1859194..1859634 - 441 WP_009935860.1 BPSL0067 family protein -
BMA10229_RS18110 1860190..1860654 + 465 WP_073699083.1 hypothetical protein -
BMA10229_RS18115 1860990..1861556 + 567 WP_004525805.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1855049..1859042 3993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T21956 WP_004199884.1 NC_008836:c1857114-1856818 [Burkholderia mallei NCTC 10229]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T21956 NC_008836:c1857114-1856818 [Burkholderia mallei NCTC 10229]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT21956 WP_004202809.1 NC_008836:c1856815-1856459 [Burkholderia mallei NCTC 10229]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT21956 NC_008836:c1856815-1856459 [Burkholderia mallei NCTC 10229]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References