Detailed information of TA system TA219557

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 789958..790615
• Replicon: chromosome
• Accession: NZ_CP084852
• Organism: Klebsiella pneumoniae strain SB2390

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LGM13_RS03910
• Protein ID: WP_004181233.1
• Coordinates: 790205..790615 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: LGM13_RS03905
• Protein ID: WP_002916312.1
• Coordinates: 789958..790224 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM13_RS03880 (785114)	785114..786547	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
LGM13_RS03885 (786666)	786666..787394	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
LGM13_RS03890 (787444)	787444..787755	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
LGM13_RS03895 (787919)	787919..788578	+	660	WP_002916317.1	hemolysin III family protein	-
LGM13_RS03900 (788729)	788729..789712	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
LGM13_RS03905 (789958)	789958..790224	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
LGM13_RS03910 (790205)	790205..790615	+	411	WP_004181233.1	protein YgfX	Toxin
LGM13_RS03915 (790622)	790622..791143	-	522	WP_004144730.1	flavodoxin FldB	-
LGM13_RS03920 (791244)	791244..792140	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
LGM13_RS03925 (792163)	792163..792876	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LGM13_RS03930 (792882)	792882..794615	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T219557 WP_004181233.1 NZ_CP084852:790205-790615 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T219557 NZ_CP116496:936825-937103 [Rickettsia asembonensis]
ATGATAATAAGCTTTAAATGTAAACATACTGAAAAATTGCATAATAGAGAATTAGTAAAACGTTTTGAAGTTTTTGCAGA
AATTGCACGTAAAAAACTCTTCATGCTTCATACTACAGTTAATTTAGAGGATTTACGTGTTCCGCCCTCAAATCGTTTAG
AATCTCTTAAAGGTGATCGTAAACATCAATATAGTATTCATATTAACAGTCAGTGGCGTATATGTTTTATTTGGCATGAT
GGAAATGTTCACAATGTTGAAATTGTAGATTATCATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT219557 WP_002916312.1 NZ_CP084852:789958-790224 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT219557 NZ_CP116496:937118-937420 [Rickettsia asembonensis]
ATGACAAACAAATTACCTCCTATTTCACCGGGGCAAATTCTACTTGAAGAATTTATGGAACCTATGGGTATTAGTCAAAG
TAAGCTTGCTCGTGATATTGATGTACCTGTTACTAGAATCAATAATATAATTAAGCATCATCGTTCAATTACTGCTGATA
CAGCACTCCGCTTAGGTAAATATTTTAATGTTAATCCTCGCTGGTGGATGAATATGCAAAATCAATATGATTTAGAACTC
GCAGAAGATGAAGGTTGGAAAGTTAAAGAAAGTAGAATAAGAACCTTTTCTATGGCAAGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41