Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 323533..324119 Replicon chromosome
Accession NZ_CP084852
Organism Klebsiella pneumoniae strain SB2390

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag LGM13_RS01505 Protein ID WP_002920800.1
Coordinates 323751..324119 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag LGM13_RS01500 Protein ID WP_004174006.1
Coordinates 323533..323754 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM13_RS01480 (319690) 319690..320616 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LGM13_RS01485 (320613) 320613..321890 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
LGM13_RS01490 (321887) 321887..322654 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LGM13_RS01495 (322656) 322656..323369 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LGM13_RS01500 (323533) 323533..323754 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LGM13_RS01505 (323751) 323751..324119 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LGM13_RS01510 (324392) 324392..325708 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LGM13_RS01515 (325815) 325815..326702 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LGM13_RS01520 (326699) 326699..327544 + 846 WP_004181473.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LGM13_RS01525 (327546) 327546..328616 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 318519..329353 10834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T219556 WP_002920800.1 NZ_CP084852:323751-324119 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T219556 NZ_CP116496:c572750-572499 [Rickettsia asembonensis]
ATGAACTCAATTAGCGGCACTTCATTTAGAAAAAACTTAAGCTCTGTACTAAATACCGTAGAAAACGATCATGTCCCTTA
TCTTATTAAAAGAAAGAATCATAAGAATATTATTCTTTTAACCGAAGAAGAATATGAATCTACAAAAGAAACATTATATT
TATTATCTAATCCGGCTAATGCTAATCGAATAAAAAAATCTATCGAACAAGCAAAAAGAGGAGAATTTGCTAAAGTTAAT
TTAGATGATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT219556 WP_004174006.1 NZ_CP084852:323533-323754 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT219556 NZ_CP116496:c572506-572243 [Rickettsia asembonensis]
ATGATTGAGATTGAGTCGACACTAGAAGCAGCGGAGGACTTAGCGTATTGGAAAAAATACGATATTAAAAAATATGAACG
TATTAAACTTCTAATAAAAAATATCCAAGAAGCACCGTTTACAGGTATAGGTAAGCCCGAACCTTTAAAACATATATTAT
CAGGTTTATGGTCACGTAGAATTAACCACGAACATAGACTAATATATTCTGTCAATCCTAAACAAATTATAATATATAAT
TGTAGATTTCATTATAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References