Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeV-yafW/CbtA-CbeA |
| Location | 4895419..4896212 | Replicon | chromosome |
| Accession | NZ_CP084843 | ||
| Organism | Klebsiella pneumoniae strain SB611 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1EZ92 |
| Locus tag | LGM15_RS24305 | Protein ID | WP_000854726.1 |
| Coordinates | 4895835..4896212 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EBQ7 |
| Locus tag | LGM15_RS24300 | Protein ID | WP_001548930.1 |
| Coordinates | 4895419..4895745 (+) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM15_RS24255 (4890857) | 4890857..4891678 | + | 822 | WP_042111319.1 | DUF932 domain-containing protein | - |
| LGM15_RS24260 (4891895) | 4891895..4892596 | + | 702 | WP_059362146.1 | WYL domain-containing protein | - |
| LGM15_RS24265 (4892637) | 4892637..4892873 | + | 237 | WP_001144031.1 | protein YpjK | - |
| LGM15_RS24270 (4892873) | 4892873..4893316 | + | 444 | WP_000649865.1 | hypothetical protein | - |
| LGM15_RS24275 (4893339) | 4893339..4893806 | + | 468 | WP_001385283.1 | protein YkfB | - |
| LGM15_RS24280 (4893883) | 4893883..4894122 | + | 240 | WP_000194654.1 | DUF905 family protein | - |
| LGM15_RS24285 (4894220) | 4894220..4894678 | + | 459 | WP_000211838.1 | antirestriction protein | - |
| LGM15_RS24290 (4894694) | 4894694..4895170 | + | 477 | WP_000811693.1 | RadC family protein | - |
| LGM15_RS24295 (4895179) | 4895179..4895400 | + | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| LGM15_RS24300 (4895419) | 4895419..4895745 | + | 327 | WP_001548930.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| LGM15_RS24305 (4895835) | 4895835..4896212 | + | 378 | WP_000854726.1 | TA system toxin CbtA family protein | Toxin |
| LGM15_RS24310 (4896209) | 4896209..4896697 | + | 489 | WP_001547769.1 | DUF5983 family protein | - |
| LGM15_RS24315 (4896709) | 4896709..4896906 | + | 198 | WP_000839269.1 | DUF957 domain-containing protein | - |
| LGM15_RS24320 (4896991) | 4896991..4897833 | + | 843 | WP_001548928.1 | DUF4942 domain-containing protein | - |
| LGM15_RS24325 (4898678) | 4898678..4898968 | - | 291 | WP_004153693.1 | PerC family transcriptional regulator | - |
| LGM15_RS24330 (4899163) | 4899163..4899285 | + | 123 | WP_004146686.1 | hypothetical protein | - |
| LGM15_RS24335 (4899280) | 4899280..4899846 | - | 567 | WP_002885396.1 | LuxR C-terminal-related transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | kpsM / kpsT / kpsS / kpsC / kpsD / kpsE / kpsF | 4866565..4899846 | 33281 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14164.10 Da Isoelectric Point: 7.8045
>T219550 WP_000854726.1 NZ_CP084843:4895835-4896212 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T219550 NZ_CP116493:c76707-76393 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12301.97 Da Isoelectric Point: 7.0273
>AT219550 WP_001548930.1 NZ_CP084843:4895419-4895745 [Klebsiella pneumoniae]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
Download Length: 327 bp
>AT219550 NZ_CP116493:c76973-76695 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|