Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4742683..4743199 Replicon chromosome
Accession NZ_CP084843
Organism Klebsiella pneumoniae strain SB611

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LGM15_RS23530 Protein ID WP_002886902.1
Coordinates 4742683..4742967 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LGM15_RS23535 Protein ID WP_002886901.1
Coordinates 4742957..4743199 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM15_RS23505 (4738158) 4738158..4738421 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LGM15_RS23510 (4738551) 4738551..4738724 + 174 WP_032414379.1 hypothetical protein -
LGM15_RS23515 (4738727) 4738727..4739470 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LGM15_RS23520 (4739827) 4739827..4741965 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LGM15_RS23525 (4742215) 4742215..4742679 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM15_RS23530 (4742683) 4742683..4742967 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM15_RS23535 (4742957) 4742957..4743199 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM15_RS23540 (4743277) 4743277..4745187 - 1911 WP_159211535.1 PRD domain-containing protein -
LGM15_RS23545 (4745210) 4745210..4746364 - 1155 WP_004178372.1 lactonase family protein -
LGM15_RS23550 (4746431) 4746431..4747171 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T219549 WP_002886902.1 NZ_CP084843:c4742967-4742683 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T219549 NZ_CP116492:202487-202798 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219549 WP_002886901.1 NZ_CP084843:c4743199-4742957 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219549 NZ_CP116492:202795-203214 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References