Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 884111..884768 Replicon chromosome
Accession NZ_CP084843
Organism Klebsiella pneumoniae strain SB611

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM15_RS04480 Protein ID WP_002916310.1
Coordinates 884358..884768 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM15_RS04475 Protein ID WP_002916312.1
Coordinates 884111..884377 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM15_RS04450 (879267) 879267..880700 - 1434 WP_159212004.1 6-phospho-beta-glucosidase -
LGM15_RS04455 (880819) 880819..881547 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGM15_RS04460 (881597) 881597..881908 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGM15_RS04465 (882072) 882072..882731 + 660 WP_002916317.1 hemolysin III family protein -
LGM15_RS04470 (882882) 882882..883865 - 984 WP_016530681.1 tRNA-modifying protein YgfZ -
LGM15_RS04475 (884111) 884111..884377 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM15_RS04480 (884358) 884358..884768 + 411 WP_002916310.1 protein YgfX Toxin
LGM15_RS04485 (884775) 884775..885296 - 522 WP_004144730.1 flavodoxin FldB -
LGM15_RS04490 (885397) 885397..886293 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM15_RS04495 (886316) 886316..887029 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM15_RS04500 (887035) 887035..888768 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219537 WP_002916310.1 NZ_CP084843:884358-884768 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219537 NZ_CP116491:354053-354400 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219537 WP_002916312.1 NZ_CP084843:884111-884377 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219537 NZ_CP116491:354400-354699 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References