Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeV-yafW/CbtA-CbeA |
| Location | 789784..790577 | Replicon | chromosome |
| Accession | NZ_CP084843 | ||
| Organism | Klebsiella pneumoniae strain SB611 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1EZ92 |
| Locus tag | LGM15_RS03985 | Protein ID | WP_000854726.1 |
| Coordinates | 789784..790161 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EBQ7 |
| Locus tag | LGM15_RS03990 | Protein ID | WP_001548930.1 |
| Coordinates | 790251..790577 (-) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM15_RS03955 (785241) | 785241..785833 | + | 593 | Protein_779 | hypothetical protein | - |
| LGM15_RS03965 (787155) | 787155..787371 | + | 217 | Protein_781 | transposase | - |
| LGM15_RS03970 (788163) | 788163..789005 | - | 843 | WP_001548928.1 | DUF4942 domain-containing protein | - |
| LGM15_RS03975 (789090) | 789090..789287 | - | 198 | WP_000839269.1 | DUF957 domain-containing protein | - |
| LGM15_RS03980 (789299) | 789299..789787 | - | 489 | WP_001547769.1 | DUF5983 family protein | - |
| LGM15_RS03985 (789784) | 789784..790161 | - | 378 | WP_000854726.1 | TA system toxin CbtA family protein | Toxin |
| LGM15_RS03990 (790251) | 790251..790577 | - | 327 | WP_001548930.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| LGM15_RS03995 (790596) | 790596..790817 | - | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| LGM15_RS04000 (790826) | 790826..791302 | - | 477 | WP_000811693.1 | RadC family protein | - |
| LGM15_RS04005 (791318) | 791318..791776 | - | 459 | WP_000211838.1 | antirestriction protein | - |
| LGM15_RS04010 (791874) | 791874..792113 | - | 240 | WP_000194654.1 | DUF905 family protein | - |
| LGM15_RS04015 (792190) | 792190..792657 | - | 468 | WP_001385283.1 | protein YkfB | - |
| LGM15_RS04020 (792680) | 792680..793123 | - | 444 | WP_000649865.1 | hypothetical protein | - |
| LGM15_RS04025 (793123) | 793123..793359 | - | 237 | WP_001144031.1 | protein YpjK | - |
| LGM15_RS04030 (793400) | 793400..794101 | - | 702 | WP_059362146.1 | WYL domain-containing protein | - |
| LGM15_RS04035 (794318) | 794318..795139 | - | 822 | WP_042111319.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | kpsF / kpsE / kpsD / kpsC / kpsS / kpsT / kpsM | 785865..820936 | 35071 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14164.10 Da Isoelectric Point: 7.8045
>T219536 WP_000854726.1 NZ_CP084843:c790161-789784 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T219536 NZ_CP116491:328082-328450 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12301.97 Da Isoelectric Point: 7.0273
>AT219536 WP_001548930.1 NZ_CP084843:c790577-790251 [Klebsiella pneumoniae]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
Download Length: 327 bp
>AT219536 NZ_CP116491:327864-328085 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|