Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 783762..784537 Replicon chromosome
Accession NZ_CP084843
Organism Klebsiella pneumoniae strain SB611

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1W1JAQ8
Locus tag LGM15_RS03950 Protein ID WP_009308645.1
Coordinates 784052..784537 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LGM15_RS03945 Protein ID WP_004150912.1
Coordinates 783762..784055 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM15_RS03925 (778969) 778969..779571 - 603 WP_002916735.1 short chain dehydrogenase -
LGM15_RS03930 (779669) 779669..780580 + 912 WP_082229051.1 LysR family transcriptional regulator -
LGM15_RS03935 (780581) 780581..781729 - 1149 WP_040223681.1 PLP-dependent aspartate aminotransferase family protein -
LGM15_RS03940 (781740) 781740..783116 - 1377 WP_194445061.1 cystathionine beta-synthase -
LGM15_RS03945 (783762) 783762..784055 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LGM15_RS03950 (784052) 784052..784537 + 486 WP_009308645.1 GNAT family N-acetyltransferase Toxin
LGM15_RS03955 (785241) 785241..785833 + 593 Protein_779 hypothetical protein -
LGM15_RS03965 (787155) 787155..787371 + 217 Protein_781 transposase -
LGM15_RS03970 (788163) 788163..789005 - 843 WP_001548928.1 DUF4942 domain-containing protein -
LGM15_RS03975 (789090) 789090..789287 - 198 WP_000839269.1 DUF957 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17595.60 Da        Isoelectric Point: 8.5144

>T219535 WP_009308645.1 NZ_CP084843:784052-784537 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T219535 NZ_CP116490:c1653893-1653588 [Haemophilus influenzae]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCTATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT219535 WP_004150912.1 NZ_CP084843:783762-784055 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT219535 NZ_CP116490:c1653577-1653254 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W1JAQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References