Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 6972..7615 | Replicon | plasmid pKp_SB612_1 |
| Accession | NZ_CP084831 | ||
| Organism | Klebsiella pneumoniae strain SB612 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A5P6KDG5 |
| Locus tag | LGM16_RS25975 | Protein ID | WP_021312768.1 |
| Coordinates | 7199..7615 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A5P6KGW8 |
| Locus tag | LGM16_RS25970 | Protein ID | WP_021312767.1 |
| Coordinates | 6972..7202 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM16_RS25935 (LGM16_25935) | 2134..2436 | + | 303 | WP_004197636.1 | hypothetical protein | - |
| LGM16_RS25940 (LGM16_25940) | 2900..3694 | - | 795 | WP_004197635.1 | site-specific integrase | - |
| LGM16_RS25945 (LGM16_25945) | 3892..4908 | - | 1017 | WP_020315256.1 | hypothetical protein | - |
| LGM16_RS25950 (LGM16_25950) | 4905..5228 | - | 324 | WP_022644730.1 | hypothetical protein | - |
| LGM16_RS25955 (LGM16_25955) | 5255..5650 | - | 396 | WP_017899885.1 | hypothetical protein | - |
| LGM16_RS25960 (LGM16_25960) | 5819..6124 | - | 306 | WP_001568026.1 | type II toxin-antitoxin system toxin CcdB | - |
| LGM16_RS25965 (LGM16_25965) | 6126..6344 | - | 219 | WP_001568025.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| LGM16_RS25970 (LGM16_25970) | 6972..7202 | + | 231 | WP_021312767.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LGM16_RS25975 (LGM16_25975) | 7199..7615 | + | 417 | WP_021312768.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LGM16_RS25980 (LGM16_25980) | 7713..7874 | - | 162 | WP_224357367.1 | helix-turn-helix domain-containing protein | - |
| LGM16_RS25985 (LGM16_25985) | 7939..8643 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| LGM16_RS25990 (LGM16_25990) | 9251..9571 | + | 321 | WP_001137910.1 | DUF134 domain-containing protein | - |
| LGM16_RS25995 (LGM16_25995) | 9546..10007 | + | 462 | WP_000626969.1 | NifB/NifX family molybdenum-iron cluster-binding protein | - |
| LGM16_RS26000 (LGM16_26000) | 10168..10605 | + | 438 | WP_016241611.1 | PaaI family thioesterase | - |
| LGM16_RS26005 (LGM16_26005) | 10720..11196 | + | 477 | WP_000043177.1 | Dps family protein | - |
| LGM16_RS26010 (LGM16_26010) | 11501..11851 | - | 351 | WP_000928911.1 | metalloregulator ArsR/SmtB family transcription factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..172669 | 172669 | |
| - | flank | IS/Tn | - | - | 7939..8655 | 716 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15175.60 Da Isoelectric Point: 7.2452
>T219531 WP_021312768.1 NZ_CP084831:7199-7615 [Klebsiella pneumoniae]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPDLVLEDWVR
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPDLVLEDWVR
Download Length: 417 bp
>T219531 NZ_CP116490:784217-784525 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8722.81 Da Isoelectric Point: 4.4692
>AT219531 WP_021312767.1 NZ_CP084831:6972-7202 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT219531 NZ_CP116490:783921-784217 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5P6KDG5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5P6KGW8 |