Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 5819..6344 | Replicon | plasmid pKp_SB612_1 |
| Accession | NZ_CP084831 | ||
| Organism | Klebsiella pneumoniae strain SB612 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | W8UQV6 |
| Locus tag | LGM16_RS25960 | Protein ID | WP_001568026.1 |
| Coordinates | 5819..6124 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | W8V2V6 |
| Locus tag | LGM16_RS25965 | Protein ID | WP_001568025.1 |
| Coordinates | 6126..6344 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM16_RS25930 (LGM16_25930) | 1511..2137 | + | 627 | WP_004197649.1 | ParA family plasmid-partitioning AAA ATPase | - |
| LGM16_RS25935 (LGM16_25935) | 2134..2436 | + | 303 | WP_004197636.1 | hypothetical protein | - |
| LGM16_RS25940 (LGM16_25940) | 2900..3694 | - | 795 | WP_004197635.1 | site-specific integrase | - |
| LGM16_RS25945 (LGM16_25945) | 3892..4908 | - | 1017 | WP_020315256.1 | hypothetical protein | - |
| LGM16_RS25950 (LGM16_25950) | 4905..5228 | - | 324 | WP_022644730.1 | hypothetical protein | - |
| LGM16_RS25955 (LGM16_25955) | 5255..5650 | - | 396 | WP_017899885.1 | hypothetical protein | - |
| LGM16_RS25960 (LGM16_25960) | 5819..6124 | - | 306 | WP_001568026.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| LGM16_RS25965 (LGM16_25965) | 6126..6344 | - | 219 | WP_001568025.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| LGM16_RS25970 (LGM16_25970) | 6972..7202 | + | 231 | WP_021312767.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| LGM16_RS25975 (LGM16_25975) | 7199..7615 | + | 417 | WP_021312768.1 | type II toxin-antitoxin system VapC family toxin | - |
| LGM16_RS25980 (LGM16_25980) | 7713..7874 | - | 162 | WP_224357367.1 | helix-turn-helix domain-containing protein | - |
| LGM16_RS25985 (LGM16_25985) | 7939..8643 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| LGM16_RS25990 (LGM16_25990) | 9251..9571 | + | 321 | WP_001137910.1 | DUF134 domain-containing protein | - |
| LGM16_RS25995 (LGM16_25995) | 9546..10007 | + | 462 | WP_000626969.1 | NifB/NifX family molybdenum-iron cluster-binding protein | - |
| LGM16_RS26000 (LGM16_26000) | 10168..10605 | + | 438 | WP_016241611.1 | PaaI family thioesterase | - |
| LGM16_RS26005 (LGM16_26005) | 10720..11196 | + | 477 | WP_000043177.1 | Dps family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..172669 | 172669 | |
| - | flank | IS/Tn | - | - | 7939..8655 | 716 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11645.32 Da Isoelectric Point: 5.6919
>T219530 WP_001568026.1 NZ_CP084831:c6124-5819 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASAWLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T219530 NZ_CP116490:c721805-721446 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAACCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACCCTATGTGAAACATTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATG
GACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACTGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAACCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACCCTATGTGAAACATTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATG
GACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACTGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8392.34 Da Isoelectric Point: 4.7405
>AT219530 WP_001568025.1 NZ_CP084831:c6344-6126 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT219530 NZ_CP116490:c721453-721157 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTATTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTATTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A514EZN1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4ZZP8 |