Detailed information of TA system TA219528

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4924129..4925810
• Replicon: chromosome
• Accession: NZ_CP084830
• Organism: Klebsiella pneumoniae strain SB612

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LGM16_RS24065
• Protein ID: WP_102086009.1
• Coordinates: 4924129..4925046 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LGM16_RS24070
• Protein ID: WP_004177809.1
• Coordinates: 4925052..4925810 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM16_RS24045 (LGM16_24045)	4919435..4920955	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
LGM16_RS24050 (LGM16_24050)	4920952..4921950	+	999	WP_002885172.1	ribose ABC transporter permease	-
LGM16_RS24055 (LGM16_24055)	4921981..4922922	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LGM16_RS24060 (LGM16_24060)	4922997..4924004	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
LGM16_RS24065 (LGM16_24065)	4924129..4925046	-	918	WP_102086009.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LGM16_RS24070 (LGM16_24070)	4925052..4925810	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LGM16_RS24075 (LGM16_24075)	4925896..4926624	-	729	WP_002885152.1	response regulator transcription factor	-
LGM16_RS24080 (LGM16_24080)	4926897..4929044	+	2148	WP_077598921.1	formate dehydrogenase subunit alpha	-
LGM16_RS24085 (LGM16_24085)	4929041..4929184	-	144	WP_019704724.1	hypothetical protein	-
LGM16_RS24090 (LGM16_24090)	4929390..4930076	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34662.10 Da
• Isoelectric Point: 5.2461

>T219528 WP_102086009.1 NZ_CP084830:c4925046-4924129 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVAWGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T219528 NZ_CP116490:400313-400717 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT219528 WP_004177809.1 NZ_CP084830:c4925810-4925052 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT219528 NZ_CP116490:400080-400316 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Structures

Antitoxin

• AlphaFold DB: A6TH05