Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4763123..4763639 Replicon chromosome
Accession NZ_CP084830
Organism Klebsiella pneumoniae strain SB612

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LGM16_RS23255 Protein ID WP_009486548.1
Coordinates 4763123..4763407 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A331AB37
Locus tag LGM16_RS23260 Protein ID WP_019704689.1
Coordinates 4763397..4763639 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM16_RS23230 (LGM16_23230) 4758519..4758782 - 264 WP_020802733.1 PTS sugar transporter subunit IIB -
LGM16_RS23235 (LGM16_23235) 4758912..4759025 + 114 Protein_4549 hypothetical protein -
LGM16_RS23240 (LGM16_23240) 4759088..4759831 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LGM16_RS23245 (LGM16_23245) 4760188..4762326 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LGM16_RS23250 (LGM16_23250) 4762655..4763119 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM16_RS23255 (LGM16_23255) 4763123..4763407 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM16_RS23260 (LGM16_23260) 4763397..4763639 - 243 WP_019704689.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM16_RS23265 (LGM16_23265) 4763717..4765627 - 1911 WP_004152270.1 PRD domain-containing protein -
LGM16_RS23270 (LGM16_23270) 4765650..4766804 - 1155 WP_019704690.1 lactonase family protein -
LGM16_RS23275 (LGM16_23275) 4766871..4767611 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T219527 WP_009486548.1 NZ_CP084830:c4763407-4763123 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T219527 NZ_CP116489:1435494-1435799 [Haemophilus influenzae]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCTATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9044.56 Da        Isoelectric Point: 8.5313

>AT219527 WP_019704689.1 NZ_CP084830:c4763639-4763397 [Klebsiella pneumoniae]
MATLNVRLDDKLKKQAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219527 NZ_CP116489:1435810-1436133 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A331AB37

References