Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4697474..4698153 Replicon chromosome
Accession NZ_CP084830
Organism Klebsiella pneumoniae strain SB612

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag LGM16_RS22945 Protein ID WP_049141568.1
Coordinates 4697474..4697794 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LGM16_RS22950 Protein ID WP_075211152.1
Coordinates 4697830..4698153 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM16_RS22915 (LGM16_22915) 4692790..4693056 + 267 WP_004178415.1 hypothetical protein -
LGM16_RS22920 (LGM16_22920) 4693056..4693728 + 673 Protein_4487 DUF4400 domain-containing protein -
LGM16_RS22925 (LGM16_22925) 4693739..4694623 + 885 WP_004192285.1 RES domain-containing protein -
LGM16_RS22930 (LGM16_22930) 4694822..4695010 - 189 Protein_4489 transposase -
LGM16_RS22935 (LGM16_22935) 4695027..4696138 - 1112 Protein_4490 IS3 family transposase -
LGM16_RS22940 (LGM16_22940) 4696524..4697360 - 837 WP_136049216.1 DUF4942 domain-containing protein -
LGM16_RS22945 (LGM16_22945) 4697474..4697794 - 321 WP_049141568.1 TA system toxin CbtA family protein Toxin
LGM16_RS22950 (LGM16_22950) 4697830..4698153 - 324 WP_075211152.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LGM16_RS22955 (LGM16_22955) 4698166..4698636 - 471 WP_049141567.1 DNA repair protein RadC -
LGM16_RS22960 (LGM16_22960) 4698707..4699528 - 822 WP_136049215.1 DUF932 domain-containing protein -
LGM16_RS22965 (LGM16_22965) 4699627..4699839 - 213 WP_049141565.1 hypothetical protein -
LGM16_RS22970 (LGM16_22970) 4699921..4700280 - 360 WP_102085841.1 hypothetical protein -
LGM16_RS22975 (LGM16_22975) 4700367..4700831 - 465 WP_102085842.1 hypothetical protein -
LGM16_RS22980 (LGM16_22980) 4700886..4701563 - 678 WP_049141562.1 WYL domain-containing protein -
LGM16_RS22985 (LGM16_22985) 4701623..4702351 - 729 WP_049141561.1 DUF3944 domain-containing protein -
LGM16_RS22990 (LGM16_22990) 4702562..4702795 - 234 WP_226617937.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4685009..4703801 18792
- flank IS/Tn - - 4702878..4703801 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(8-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12017.64 Da        Isoelectric Point: 5.9559

>T219526 WP_049141568.1 NZ_CP084830:c4697794-4697474 [Klebsiella pneumoniae]
MHISTVPATVPVSSRLSSVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAILEHIEAGITLADAVNFLVERYELVRTDRKGF
TWQEQTPFLTATDILRARRATGLINT

Download         Length: 321 bp

>T219526 NZ_CP116489:1332317-1332565 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12026.68 Da        Isoelectric Point: 5.4946

>AT219526 WP_075211152.1 NZ_CP084830:c4698153-4697830 [Klebsiella pneumoniae]
MSFTLPYEWGLQSNITPRFGARLVQEGNRLYYLADRAGLTGSFSPIHLQKLDLAFPLFVEQLENMLSAGELNPHQQHQVT
IQLASLTCIADTPGSYGYVYISFYPTP

Download         Length: 324 bp

>AT219526 NZ_CP116489:1332562-1332906 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References