Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4059067..4059686 Replicon chromosome
Accession NZ_CP084830
Organism Klebsiella pneumoniae strain SB612

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM16_RS19885 Protein ID WP_002892050.1
Coordinates 4059468..4059686 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM16_RS19880 Protein ID WP_002892066.1
Coordinates 4059067..4059441 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM16_RS19870 (LGM16_19870) 4054219..4055412 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGM16_RS19875 (LGM16_19875) 4055435..4058581 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LGM16_RS19880 (LGM16_19880) 4059067..4059441 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM16_RS19885 (LGM16_19885) 4059468..4059686 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM16_RS19890 (LGM16_19890) 4059845..4060411 + 567 WP_002892030.1 maltose O-acetyltransferase -
LGM16_RS19895 (LGM16_19895) 4060383..4060523 - 141 WP_032409038.1 hypothetical protein -
LGM16_RS19900 (LGM16_19900) 4060544..4061014 + 471 WP_002892026.1 YlaC family protein -
LGM16_RS19905 (LGM16_19905) 4060989..4062439 - 1451 Protein_3901 PLP-dependent aminotransferase family protein -
LGM16_RS19910 (LGM16_19910) 4062540..4063238 + 699 WP_019705329.1 GNAT family protein -
LGM16_RS19915 (LGM16_19915) 4063235..4063375 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM16_RS19920 (LGM16_19920) 4063375..4063638 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219524 WP_002892050.1 NZ_CP084830:4059468-4059686 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219524 NZ_CP116489:c1014799-1014509 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACTATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219524 WP_002892066.1 NZ_CP084830:4059067-4059441 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219524 NZ_CP116489:c1015043-1014789 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCCGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAGCTCGGCAGAATGGCAAATGAACGGCTAGCCACCCTAGAACCAGTAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References