Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2671989..2673577 Replicon chromosome
Accession NZ_CP084830
Organism Klebsiella pneumoniae strain SB612

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LGM16_RS13230 Protein ID WP_019705665.1
Coordinates 2671989..2673311 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LGM16_RS13235 Protein ID WP_004176198.1
Coordinates 2673311..2673577 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM16_RS13215 (LGM16_13215) 2667045..2669546 + 2502 WP_064181310.1 fimbria/pilus outer membrane usher protein -
LGM16_RS13220 (LGM16_13220) 2669534..2670538 + 1005 WP_004184029.1 fimbrial protein -
LGM16_RS13225 (LGM16_13225) 2670680..2671972 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LGM16_RS13230 (LGM16_13230) 2671989..2673311 - 1323 WP_019705665.1 type II toxin-antitoxin system HipA family toxin Toxin
LGM16_RS13235 (LGM16_13235) 2673311..2673577 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LGM16_RS13240 (LGM16_13240) 2673843..2674169 - 327 WP_019705664.1 hydroxyisourate hydrolase -
LGM16_RS13245 (LGM16_13245) 2674166..2674666 - 501 WP_019705663.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LGM16_RS13250 (LGM16_13250) 2674644..2676023 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
LGM16_RS13255 (LGM16_13255) 2676369..2677523 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LGM16_RS13260 (LGM16_13260) 2677504..2678427 - 924 WP_019705662.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2467201..2708142 240941


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5358

>T219522 WP_019705665.1 NZ_CP084830:c2673311-2671989 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T219522 NZ_CP116489:c721820-721461 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAACCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACCCTATGTGAAACATTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATG
GACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACTGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT219522 WP_004176198.1 NZ_CP084830:c2673577-2673311 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT219522 NZ_CP116489:c721468-721172 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTATTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References