Detailed information of TA system TA021952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 2507450..2508345
• Replicon: chromosome
• Accession: NC_008825
• Organism: Methylibium petroleiphilum PM1

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: A2SIA5
• Locus tag: MPE_RS11800
• Protein ID: WP_011829931.1
• Coordinates: 2507818..2508345 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: A2SIA4
• Locus tag: MPE_RS11795
• Protein ID: WP_011829930.1
• Coordinates: 2507450..2507821 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPE_RS11765	2502550..2502768	+	219	WP_011829925.1	AlpA family transcriptional regulator	-
MPE_RS11770	2502809..2503675	+	867	WP_041929662.1	ParA family protein	-
MPE_RS11775	2503659..2503895	+	237	WP_041929663.1	type II toxin-antitoxin system HicA family toxin	-
MPE_RS11780	2503888..2505546	+	1659	WP_011829927.1	ParB family protein	-
MPE_RS11785	2505564..2506124	+	561	WP_011829928.1	DUF2857 domain-containing protein	-
MPE_RS11790	2506127..2507329	+	1203	WP_011829929.1	hypothetical protein	-
MPE_RS11795	2507450..2507821	+	372	WP_011829930.1	hypothetical protein	Antitoxin
MPE_RS11800	2507818..2508345	+	528	WP_011829931.1	RES family NAD+ phosphorylase	Toxin
MPE_RS11805	2508529..2509317	+	789	WP_011829932.1	TIGR03761 family integrating conjugative element protein	-
MPE_RS11810	2509314..2509862	+	549	WP_011829933.1	DUF3158 family protein	-
MPE_RS11815	2509859..2510242	+	384	WP_004362284.1	single-stranded DNA-binding protein	-
MPE_RS11820	2510537..2512552	+	2016	WP_011829934.1	DNA topoisomerase III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2498157..2574031	75874

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (11-169)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19816.27 Da
• Isoelectric Point: 5.5617

>T21952 WP_011829931.1 NC_008825:2507818-2508345 [Methylibium petroleiphilum PM1]
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEVTALREYQQTSPFLPPCTMCSYTANLRGL
VDLRQLHRGEPWDELWHDWREDWRHLKFELHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR

Nucleotide

• Length: 528 bp

>T21952 NC_008825:2507818-2508345 [Methylibium petroleiphilum PM1]
ATGATCCTCCTCGACCTGCCGCCCGGCACCACGCTGTTTCGTGCGCACACGCCGCAGTGGGCCAGCCGGCCCACCAGCGG
CGCCGGTGCGGCGGCCAAGGGCGGTCGCTTCAACCGGGAGGGCGTCGAGGCGCTGTATCTGTCGCTGGAGGAAGTGACCG
CGTTACGCGAGTACCAGCAGACCTCGCCCTTCCTGCCGCCCTGCACGATGTGCTCGTACACCGCGAACTTGCGCGGACTG
GTCGATCTGCGGCAGCTCCACCGCGGCGAGCCCTGGGACGAGCTGTGGCACGACTGGCGCGAGGACTGGCGCCATCTGAA
ATTCGAACTTCACATCGAGCCGCCCACCTGGGTGCTGGGCGACATGGTGCTGGCCCAGGGCCATACCGGAATCCTGTTCC
CCAGCCAGGCGAACGATGGCGGCACCAATATCGTGGTGTTCGTGGATCGGCTCAGGGATGGCAATTCGGTCGAGGTCAAT
GATCCCGACGGGCGACTGCCCCGCGACCAATCCAGTTGGACGCGCTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13342.05 Da
• Isoelectric Point: 6.0705

>AT21952 WP_011829930.1 NC_008825:2507450-2507821 [Methylibium petroleiphilum PM1]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAATAVQPDTAR
AFFMVKNEPIPAFHHKTLLQLVQEGRTDDAIDYLESISAGFTG

Nucleotide

• Length: 372 bp

>AT21952 NC_008825:2507450-2507821 [Methylibium petroleiphilum PM1]
ATGGCCTCTACCGCTTTCGCGGATGTGCTCGAATCGGTGCGTGAAGCCGGCACGTCCCGCTTTTCCGCCACGAACGTCGC
CGATGCCCTGGGCCTGCAGTACCAGGACTTGGCCACGCTGGCTGGGGTGCACCGCAACACCCTGCGCACCCACCCCGAAT
CCCCGCGGCTCCAGGCCGCGCTGCGTGACCTGATGCGGGTGCTGTCGGCCGCCACGGCGGTGCAGCCGGATACCGCGCGT
GCGTTCTTCATGGTCAAGAACGAACCCATTCCGGCGTTCCACCACAAGACCCTGCTGCAGTTGGTGCAGGAAGGACGCAC
CGACGATGCGATCGACTACCTGGAGTCGATCAGTGCAGGGTTCACCGGATGA

Structures

Toxin

• AlphaFold DB: A2SIA5

Antitoxin

• AlphaFold DB: A2SIA4