Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 801100..801757 Replicon chromosome
Accession NZ_CP084830
Organism Klebsiella pneumoniae strain SB612

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM16_RS04000 Protein ID WP_002916310.1
Coordinates 801347..801757 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM16_RS03995 Protein ID WP_002916312.1
Coordinates 801100..801366 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM16_RS03970 (LGM16_03970) 796308..797741 - 1434 WP_019704912.1 6-phospho-beta-glucosidase BglA -
LGM16_RS03975 (LGM16_03975) 797860..798588 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGM16_RS03980 (LGM16_03980) 798638..798949 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGM16_RS03985 (LGM16_03985) 799113..799772 + 660 WP_002916317.1 hemolysin III family protein -
LGM16_RS03990 (LGM16_03990) 799871..800854 - 984 WP_016530681.1 tRNA-modifying protein YgfZ -
LGM16_RS03995 (LGM16_03995) 801100..801366 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM16_RS04000 (LGM16_04000) 801347..801757 + 411 WP_002916310.1 protein YgfX Toxin
LGM16_RS04005 (LGM16_04005) 801764..802285 - 522 WP_004144730.1 flavodoxin FldB -
LGM16_RS04010 (LGM16_04010) 802386..803282 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM16_RS04015 (LGM16_04015) 803305..804018 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM16_RS04020 (LGM16_04020) 804024..805757 + 1734 WP_019704911.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219513 WP_002916310.1 NZ_CP084830:801347-801757 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219513 NZ_CP116480:c4365930-4365712 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219513 WP_002916312.1 NZ_CP084830:801100-801366 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219513 NZ_CP116480:c4366330-4365956 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References