Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3917704..3918323 Replicon chromosome
Accession NZ_CP084829
Organism Klebsiella pneumoniae strain SB615

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM17_RS19215 Protein ID WP_002892050.1
Coordinates 3918105..3918323 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM17_RS19210 Protein ID WP_002892066.1
Coordinates 3917704..3918078 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM17_RS19200 (3912856) 3912856..3914049 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGM17_RS19205 (3914072) 3914072..3917218 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LGM17_RS19210 (3917704) 3917704..3918078 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM17_RS19215 (3918105) 3918105..3918323 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM17_RS19220 (3918486) 3918486..3919052 + 567 WP_002892030.1 maltose O-acetyltransferase -
LGM17_RS19225 (3919024) 3919024..3919164 - 141 WP_226617261.1 hypothetical protein -
LGM17_RS19230 (3919185) 3919185..3919655 + 471 WP_002892026.1 YlaC family protein -
LGM17_RS19235 (3919630) 3919630..3921081 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LGM17_RS19240 (3921182) 3921182..3921880 + 699 WP_002892021.1 GNAT family protein -
LGM17_RS19245 (3921877) 3921877..3922017 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM17_RS19250 (3922017) 3922017..3922280 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219506 WP_002892050.1 NZ_CP084829:3918105-3918323 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219506 NZ_CP116480:c2873468-2873361 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219506 WP_002892066.1 NZ_CP084829:3917704-3918078 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219506 NZ_CP116480:2873525-2873580 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References