Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2536716..2538304 Replicon chromosome
Accession NZ_CP084829
Organism Klebsiella pneumoniae strain SB615

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag LGM17_RS12430 Protein ID WP_023301940.1
Coordinates 2536716..2538038 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LGM17_RS12435 Protein ID WP_002904790.1
Coordinates 2538038..2538304 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM17_RS12415 (2531772) 2531772..2534273 + 2502 WP_023342811.1 fimbria/pilus outer membrane usher protein -
LGM17_RS12420 (2534261) 2534261..2535265 + 1005 WP_004184029.1 fimbrial protein -
LGM17_RS12425 (2535407) 2535407..2536699 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LGM17_RS12430 (2536716) 2536716..2538038 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
LGM17_RS12435 (2538038) 2538038..2538304 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LGM17_RS12440 (2538569) 2538569..2538895 - 327 WP_109217496.1 hydroxyisourate hydrolase -
LGM17_RS12445 (2538892) 2538892..2539392 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LGM17_RS12450 (2539370) 2539370..2540749 - 1380 WP_021462562.1 nucleobase:cation symporter-2 family protein -
LGM17_RS12455 (2541095) 2541095..2542249 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LGM17_RS12460 (2542230) 2542230..2543153 - 924 WP_109217497.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T219505 WP_023301940.1 NZ_CP084829:c2538038-2536716 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T219505 NZ_CP116480:c2872985-2872878 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT219505 WP_002904790.1 NZ_CP084829:c2538304-2538038 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT219505 NZ_CP116480:2873033-2873099 [Escherichia coli]
GGTCTAGATGCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References