Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 536936..537492 Replicon chromosome
Accession NC_008818
Organism Hyperthermus butylicus DSM 5456

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HBUT_RS02925 Protein ID WP_011821742.1
Coordinates 537214..537492 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HBUT_RS02920 Protein ID WP_048061410.1
Coordinates 536936..537166 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBUT_RS02890 (Hbut_0557) 532369..533121 + 753 WP_011821735.1 dihydrofolate reductase family protein -
HBUT_RS02895 (Hbut_0558) 533230..533949 + 720 WP_011821736.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
HBUT_RS02900 (Hbut_0559) 533897..534373 + 477 WP_048061409.1 riboflavin synthase -
HBUT_RS02905 (Hbut_0560) 534432..534896 + 465 WP_011821738.1 6,7-dimethyl-8-ribityllumazine synthase -
HBUT_RS02910 (Hbut_0561) 534874..536025 + 1152 WP_228546783.1 amidohydrolase family protein -
HBUT_RS02915 (Hbut_0562) 536084..536818 - 735 WP_011821740.1 creatininase family protein -
HBUT_RS02920 (Hbut_0563) 536936..537166 + 231 WP_048061410.1 ribbon-helix-helix protein, CopG family Antitoxin
HBUT_RS02925 (Hbut_0564) 537214..537492 + 279 WP_011821742.1 hypothetical protein Toxin
HBUT_RS02930 (Hbut_0565) 537829..538572 + 744 WP_011821743.1 HesA/MoeB/ThiF family protein -
HBUT_RS02935 (Hbut_0566) 538581..539747 + 1167 WP_011821744.1 tRNA uracil 4-sulfurtransferase ThiI -
HBUT_RS02940 (Hbut_0567) 539725..540366 - 642 WP_011821745.1 hypothetical protein -
HBUT_RS02945 (Hbut_0568) 540786..541517 + 732 WP_011821746.1 archaeal proteasome endopeptidase complex subunit alpha -
HBUT_RS02950 (Hbut_0569) 541521..542234 + 714 WP_011821747.1 ribosome assembly factor SBDS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10503.31 Da        Isoelectric Point: 4.6749

>T21950 WP_011821742.1 NC_008818:537214-537492 [Hyperthermus butylicus DSM 5456]
MLLRRIRLELLADNYIQWLTIYEALNAVWKEAMLLHRLIREEAAGLAEVIAELAGLMRVLDPRGSELEIVERAHELGLTV
YDASYVVLAEKA

Download         Length: 279 bp

>T21950 NC_008818:537214-537492 [Hyperthermus butylicus DSM 5456]
ATGCTATTAAGAAGGATAAGGCTGGAGCTGCTAGCGGACAATTATATCCAGTGGCTTACAATCTATGAGGCACTTAATGC
TGTGTGGAAGGAGGCGATGCTGCTTCACAGACTGATCCGTGAGGAGGCTGCAGGTCTTGCAGAGGTTATAGCAGAGTTGG
CAGGGTTAATGCGCGTGCTAGATCCACGGGGCAGCGAGCTAGAGATAGTGGAGAGGGCACATGAGCTAGGCTTGACAGTA
TACGACGCATCATATGTTGTTTTAGCGGAAAAAGCATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9157.59 Da        Isoelectric Point: 9.8542

>AT21950 WP_048061410.1 NC_008818:536936-537166 [Hyperthermus butylicus DSM 5456]
VNRYVTVSAKIRRELKEEAERLGIDFSEVIRRAIEEEVKRRKLQLLREKLNGLRGALEKIDVEEIVELIRRDREER

Download         Length: 231 bp

>AT21950 NC_008818:536936-537166 [Hyperthermus butylicus DSM 5456]
GTGAATAGGTATGTGACCGTGTCTGCTAAGATACGCCGCGAACTTAAAGAGGAGGCCGAAAGGCTCGGTATAGACTTCTC
TGAGGTTATAAGAAGGGCTATAGAGGAGGAGGTTAAGCGGAGGAAGCTCCAGCTACTTCGTGAGAAGCTTAACGGTCTGA
GAGGCGCCCTGGAAAAAATTGATGTTGAAGAAATTGTGGAGCTAATTAGGAGGGATCGTGAGGAACGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References