Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797713..798370 Replicon chromosome
Accession NZ_CP084829
Organism Klebsiella pneumoniae strain SB615

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM17_RS03950 Protein ID WP_002916310.1
Coordinates 797960..798370 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM17_RS03945 Protein ID WP_002916312.1
Coordinates 797713..797979 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM17_RS03920 (792869) 792869..794302 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LGM17_RS03925 (794421) 794421..795149 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGM17_RS03930 (795199) 795199..795510 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGM17_RS03935 (795674) 795674..796333 + 660 WP_002916317.1 hemolysin III family protein -
LGM17_RS03940 (796484) 796484..797467 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
LGM17_RS03945 (797713) 797713..797979 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM17_RS03950 (797960) 797960..798370 + 411 WP_002916310.1 protein YgfX Toxin
LGM17_RS03955 (798377) 798377..798898 - 522 WP_004144730.1 flavodoxin FldB -
LGM17_RS03960 (798999) 798999..799895 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM17_RS03965 (799918) 799918..800631 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM17_RS03970 (800637) 800637..802370 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219496 WP_002916310.1 NZ_CP084829:797960-798370 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219496 NZ_CP116480:c1039180-1039077 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219496 WP_002916312.1 NZ_CP084829:797713-797979 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219496 NZ_CP116480:1039039-1039310 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References