Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4742099..4742615 Replicon chromosome
Accession NZ_CP084825
Organism Klebsiella pneumoniae strain SB617

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LGM18_RS23285 Protein ID WP_040237797.1
Coordinates 4742099..4742383 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LGM18_RS23290 Protein ID WP_002886901.1
Coordinates 4742373..4742615 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM18_RS23260 (4737515) 4737515..4737778 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LGM18_RS23265 (4737908) 4737908..4738081 + 174 WP_032410138.1 hypothetical protein -
LGM18_RS23270 (4738084) 4738084..4738827 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
LGM18_RS23275 (4739184) 4739184..4741322 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LGM18_RS23280 (4741631) 4741631..4742095 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM18_RS23285 (4742099) 4742099..4742383 - 285 WP_040237797.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM18_RS23290 (4742373) 4742373..4742615 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM18_RS23295 (4742693) 4742693..4744603 - 1911 WP_009486549.1 PRD domain-containing protein -
LGM18_RS23300 (4744626) 4744626..4745780 - 1155 WP_131073266.1 lactonase family protein -
LGM18_RS23305 (4745847) 4745847..4746587 - 741 WP_064167571.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11067.91 Da        Isoelectric Point: 10.4962

>T219492 WP_040237797.1 NZ_CP084825:c4742383-4742099 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T219492 NZ_CP116480:c364833-364726 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219492 WP_002886901.1 NZ_CP084825:c4742615-4742373 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219492 NZ_CP116480:364883-364946 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References