21949

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhoH-LOG/-
Location 1079815..1082128 Replicon chromosome
Accession NC_008817
Organism Prochlorococcus marinus str. MIT 9515

Toxin (Protein)


Gene name PhoH Uniprot ID A2BXB6
Locus tag P9515_RS05910 Protein ID WP_011820526.1
Coordinates 1079815..1081206 (+) Length 464 a.a.

Antitoxin (Protein)


Gene name LOG Uniprot ID A2BXB7
Locus tag P9515_RS05915 Protein ID WP_011820527.1
Coordinates 1081244..1082128 (+) Length 295 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9515_RS05900 1075646..1077241 - 1596 WP_011820524.1 DNA recombination protein RmuC -
P9515_RS05905 1077767..1078738 - 972 WP_011820525.1 phosphate ABC transporter substrate-binding protein PstS -
P9515_RS05910 1079815..1081206 + 1392 WP_011820526.1 PhoH family protein Toxin
P9515_RS05915 1081244..1082128 + 885 WP_011820527.1 LOG family protein Antitoxin
P9515_RS05920 1082440..1082703 - 264 WP_011820528.1 DUF1651 domain-containing protein -
P9515_RS05925 1082766..1082945 - 180 WP_011820529.1 hypothetical protein -
P9515_RS05930 1082942..1083289 - 348 WP_011820530.1 DUF1330 domain-containing protein -
P9515_RS09360 1083860..1083976 - 117 WP_011820532.1 50S ribosomal protein L36 -
P9515_RS05935 1084057..1084275 + 219 WP_011820533.1 hypothetical protein -
P9515_RS05940 1084603..1085334 - 732 WP_187146044.1 amino acid ABC transporter ATP-binding protein -
P9515_RS05945 1085354..1086373 - 1020 WP_011820536.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-150)

Antitoxin

LOG family

(157-285)


Sequences

Toxin        


Download         Length: 464 a.a.        Molecular weight: 52010.67 Da        Isoelectric Point: 9.0721

>T21949 WP_011820526.1 NC_008817:1079815-1081206 [Prochlorococcus marinus str. MIT 9515]
MKKRVIVLDTNVLLHDPESPLHFTKDDVVIPIQVVEEVDRFKRDPSEKGRNARRVSRLLDSFRERGNLSSGVRINNKDAG
QIKVAFCRKETTDRLPSELNDNSGDNKILAVALEHKTNKVLANSPDVILISKDTNLRIKADAIGLKAEDYSSNKISLDNL
NRGFREVISDQNEINKIQKEGFIFLKDIKFNLKPSLYSNEGVILRDNLKENHTYLCRYDPIEKKLISLNWLRRSNLGKIK
PKNLEQSFALDLLLDPDIQLVTLIGKAGTGKTLLALAVGLNLVADENMYERLLVSRPPISLGKELGFLPGSLDEKLAPWM
KPIIDNLDYLTGSKFNKKGEKVAPKERDNNARNSWEDLKGMGLLEVEAINYIRGRSISHQFILIDEAQNLTPLEVKTIVT
RAGEGTKIVFTGDPNQIDHPYLDSDSNGLTWLAKKLQGQKIVGHITLSQGERSDLAELAANIL

Download         Length: 1392 bp

>T21949 NC_008817:1079815-1081206 [Prochlorococcus marinus str. MIT 9515]
ATGAAAAAAAGAGTCATAGTATTAGATACCAACGTTCTTTTACATGATCCGGAATCTCCACTTCATTTCACTAAAGATGA
TGTTGTTATTCCAATTCAAGTAGTTGAAGAGGTCGATAGGTTTAAGCGTGATCCAAGTGAAAAAGGCAGGAATGCCCGAA
GAGTTTCTAGATTATTGGATAGCTTTAGAGAGAGAGGGAATTTATCTTCTGGTGTGAGAATAAATAATAAAGATGCAGGT
CAAATAAAAGTTGCTTTCTGTAGAAAAGAAACTACTGATAGGTTACCCTCTGAGTTAAATGACAATAGTGGAGATAACAA
GATTTTAGCGGTTGCTCTTGAACACAAAACTAATAAGGTATTGGCAAATTCTCCAGATGTAATTCTCATCTCTAAAGATA
CAAATTTAAGGATAAAGGCGGATGCAATTGGATTAAAAGCGGAAGACTACAGTAGCAATAAAATTTCTTTAGATAATTTA
AATAGAGGATTTAGAGAGGTTATTTCTGATCAAAATGAAATTAATAAAATTCAAAAAGAAGGATTCATCTTTTTAAAAGA
TATTAAATTCAATTTAAAGCCAAGCTTATATTCTAATGAAGGTGTAATTCTCAGGGATAATCTTAAAGAAAATCATACAT
ATTTATGCAGATATGACCCTATAGAAAAGAAATTGATTTCTTTGAATTGGTTAAGAAGATCTAATTTAGGAAAAATAAAA
CCAAAAAATTTAGAACAAAGTTTTGCCTTGGATTTGCTCCTTGATCCAGATATTCAGTTGGTTACTCTTATAGGAAAAGC
AGGTACAGGAAAAACTTTATTGGCATTAGCTGTGGGATTAAATTTAGTTGCAGATGAAAATATGTATGAAAGATTATTAG
TCTCAAGACCTCCAATTTCTTTGGGGAAAGAATTAGGATTTCTTCCAGGCAGTTTAGATGAAAAATTAGCTCCATGGATG
AAACCTATTATTGATAACTTGGATTATTTAACAGGCTCAAAATTTAATAAAAAAGGTGAAAAAGTTGCACCTAAAGAGAG
AGATAATAATGCAAGAAATTCATGGGAAGATCTCAAAGGGATGGGACTTTTAGAGGTTGAAGCAATCAATTATATTCGCG
GAAGGTCAATTTCACATCAATTTATTCTTATTGATGAGGCTCAAAATTTAACGCCTTTAGAAGTTAAGACGATCGTTACT
AGGGCTGGTGAAGGTACAAAAATTGTATTCACTGGGGATCCAAATCAAATAGATCATCCTTATTTAGACTCTGATAGTAA
TGGTCTTACATGGTTGGCTAAAAAACTTCAGGGTCAGAAAATAGTTGGCCATATTACCCTGTCACAAGGCGAAAGAAGTG
ATTTAGCTGAATTGGCCGCAAATATCTTGTGA

Antitoxin


Download         Length: 295 a.a.        Molecular weight: 33510.69 Da        Isoelectric Point: 8.1466

>AT21949 WP_011820527.1 NC_008817:1081244-1082128 [Prochlorococcus marinus str. MIT 9515]
MKKNLNCDFAKERSNEAQVVASNLEAILKSNSYKLAHEDLELLNTDEMRGVRMLLEITKPDQAIEKENIISTVIIFGGVH
ISEEITSKRRLDETSKLLEKDPKSTLLMQKVKRYKNLYSMSHYYSSARELSKLISIETKLERPHAHVIVTGGGPGIMEAA
NRGAFDAGCKSIGLNISLPNEQHPNSFITPGLCFKFNYFAMRKFHFVMRSEAAVFFPGGFGTLDELFELLTLRQTGMKKN
IPIILFGRDYWNKVINFEYLCDMGLIEEKHLSIFKYADSAHEAWALIKKFNNSD

Download         Length: 885 bp

>AT21949 NC_008817:1081244-1082128 [Prochlorococcus marinus str. MIT 9515]
ATGAAAAAAAATTTAAATTGTGATTTTGCAAAAGAACGAAGTAATGAGGCTCAAGTCGTCGCTAGTAATTTAGAAGCAAT
TTTAAAATCTAACTCTTATAAACTTGCGCATGAAGATTTGGAATTACTAAATACTGATGAAATGCGAGGCGTTCGAATGC
TTCTTGAAATAACGAAGCCTGATCAAGCGATTGAAAAGGAAAATATAATTTCTACGGTTATTATTTTTGGTGGCGTTCAT
ATATCAGAAGAAATCACTTCAAAGAGAAGATTGGACGAGACTTCAAAACTTCTTGAAAAAGATCCAAAATCTACTTTGTT
AATGCAAAAAGTAAAAAGATATAAGAATCTATATTCAATGTCTCACTATTATTCTTCAGCTAGGGAATTATCTAAGTTAA
TATCAATTGAAACAAAATTAGAACGTCCTCATGCTCATGTGATAGTAACTGGGGGTGGACCTGGGATTATGGAAGCTGCT
AATAGAGGGGCTTTTGATGCGGGTTGTAAATCTATTGGATTAAATATTAGTTTACCTAATGAACAGCATCCAAATTCATT
TATTACTCCGGGATTATGTTTTAAGTTTAACTATTTTGCTATGAGGAAATTTCATTTTGTTATGAGATCTGAGGCCGCAG
TTTTTTTCCCCGGTGGATTCGGAACTTTAGATGAATTATTTGAATTATTAACTTTGAGGCAAACTGGGATGAAGAAAAAT
ATACCAATTATTTTATTTGGAAGAGATTATTGGAACAAAGTAATTAATTTTGAATATCTATGCGATATGGGTTTAATAGA
GGAAAAGCATTTATCAATTTTTAAATATGCTGACAGTGCTCATGAGGCTTGGGCTTTGATAAAGAAGTTTAACAATAGTG
ATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A2BXB6

Antitoxin

Source ID Structure
AlphaFold DB A2BXB7

References