Detailed information of TA system TA219487

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2588103..2589691
• Replicon: chromosome
• Accession: NZ_CP084825
• Organism: Klebsiella pneumoniae strain SB617

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A6T928
• Locus tag: LGM18_RS12715
• Protein ID: WP_004176197.1
• Coordinates: 2588103..2589425 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LGM18_RS12720
• Protein ID: WP_032417111.1
• Coordinates: 2589425..2589691 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM18_RS12700 (2583159)	2583159..2585660	+	2502	Protein_2484	fimbrial biogenesis outer membrane usher protein	-
LGM18_RS12705 (2585648)	2585648..2586652	+	1005	WP_004176196.1	fimbrial protein	-
LGM18_RS12710 (2586794)	2586794..2588086	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LGM18_RS12715 (2588103)	2588103..2589425	-	1323	WP_004176197.1	type II toxin-antitoxin system HipA family toxin	Toxin
LGM18_RS12720 (2589425)	2589425..2589691	-	267	WP_032417111.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LGM18_RS12725 (2589956)	2589956..2590282	-	327	WP_064291485.1	hydroxyisourate hydrolase	-
LGM18_RS12730 (2590279)	2590279..2590779	-	501	WP_064291486.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LGM18_RS12735 (2590757)	2590757..2592136	-	1380	WP_004215088.1	nucleobase:cation symporter-2 family protein	-
LGM18_RS12740 (2592482)	2592482..2593636	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LGM18_RS12745 (2593617)	2593617..2594540	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49111.41 Da
• Isoelectric Point: 7.5357

>T219487 WP_004176197.1 NZ_CP084825:c2589425-2588103 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T219487 NZ_CP116478:c1718302-1718012 [Pseudomonas syringae pv. actinidiae]
TTGACCTTTAAGCTCGAGTTTCTGCCTTCAGCCCTGAAAGAGTGGAAAAAACTGGGGCATACCGTTAGTGCTCAACTCAA
GAAAAAGCTTTTGGAGCGGCTCGAATTACCTCGAAATGCGGGCGATGCGCTGCATGGCATGCCCGATCACTACAAAATCA
AGTTGCGCAGTGCTGGTTACAGACTGGTTTACCGGGTGGAAGATGATCGGGTAGTAGTGACCGTCGTCGCTGTAGGCAAG
CGCGAACGAGGCGATATCTACGATTCAGCCAAGGACAGGCTGTCTCCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9926.32 Da
• Isoelectric Point: 8.5912

>AT219487 WP_032417111.1 NZ_CP084825:c2589691-2589425 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETASAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT219487 NZ_CP116478:c1718537-1718292 [Pseudomonas syringae pv. actinidiae]
ATGCAAAATATCTTTGCGGACATCGCGGTCAGCGTCTCTGAACTGAAGAAAAACCCGTCAGCCGTCCTGAGCGGCGCACA
AGGCTTGCCCGTCGCAGTACTCAATCACAATAAAGTCATGGGCTACATGGTGCCTGCCGAGGTGTTTGAAGCAATGATGA
AGCGCCTTGATGACCTCGATCTGGCCGACCTGATCAAAGCCAGGCAACATGAAAAGCCGGTATCGGTAGATATACTTGAC
CTTTAA

Structures

Toxin

• AlphaFold DB: A6T928