Detailed information of TA system TA021948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 4533934..4534577
• Replicon: chromosome
• Accession: NC_008800
• Organism: Yersinia enterocolitica subsp. enterocolitica 8081

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: A1JT39
• Locus tag: YE_RS20760
• Protein ID: WP_011817440.1
• Coordinates: 4533934..4534353 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: YE_RS20765
• Protein ID: WP_023517661.1
• Coordinates: 4534350..4534577 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE_RS20740 (YE4137)	4529119..4529973	+	855	WP_071881813.1	formate dehydrogenase accessory sulfurtransferase FdhD	-
YE_RS20745 (YE4138)	4530100..4530723	+	624	WP_011817437.1	superoxide dismutase [Mn]	-
YE_RS20750 (YE4139)	4531081..4533030	+	1950	WP_011817438.1	methyl-accepting chemotaxis protein	-
YE_RS20755 (YE4140)	4533109..4533780	+	672	WP_011817439.1	6-N-hydroxylaminopurine resistance protein	-
YE_RS20760 (YE4141)	4533934..4534353	-	420	WP_011817440.1	type II toxin-antitoxin system VapC family toxin	Toxin
YE_RS20765 (YE4142)	4534350..4534577	-	228	WP_023517661.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
YE_RS20770 (YE4143)	4534879..4535235	-	357	WP_005161962.1	YibL family ribosome-associated protein	-
YE_RS20775 (YE4144)	4535328..4536809	-	1482	WP_011817442.1	PLP-dependent aminotransferase family protein	-
YE_RS20780 (YE4145)	4536954..4537565	+	612	WP_005175072.1	LysE family translocator	-
YE_RS20785 (YE4146)	4537562..4538116	-	555	WP_005161972.1	MltR family transcriptional regulator	-
YE_RS20790 (YE4147)	4538231..4539394	-	1164	WP_011817444.1	mannitol-1-phosphate 5-dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-131)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15676.36 Da
• Isoelectric Point: 9.7772

>T21948 WP_011817440.1 NC_008800:c4534353-4533934 [Yersinia enterocolitica subsp. enterocolitica 8081]
MIKKLYMLDTNICSFIIRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDVIWPWDI
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIRKFERVKKLRIEDWTQ

Nucleotide

• Length: 420 bp

>T21948 NC_008800:c4534353-4533934 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGATCAAAAAATTATATATGCTTGATACGAATATTTGTTCTTTTATTATACGGGAACGACCAGCAGAATTAATTATAAA
ACTACAACAGTGTATTGAGCATCAGAATAAAATAGTTGTCTCAGCAATTACATACTCAGAAATGCGGTTTGGCGCTATAG
GTAAGAAAGCATCTCCAAAGCATAATTATTTAGTTGATGAATTTGTAAAAAGGTTAGATGTTATTTGGCCGTGGGATATC
GCAGCTGTTGATGCCACGACTAATATTAAGGTTGAGCTGGCAAAGCAGGGGACACCAATTGGTGGAAATGATGCCGCAAT
AGCCGGGCACGCAGTTTCTGCTGGAGCAATATTAGTCACTAATAATATTAGAAAGTTTGAACGAGTTAAAAAACTACGAA
TTGAAGATTGGACTCAATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8785.93 Da
• Isoelectric Point: 4.2687

>AT21948 WP_023517661.1 NC_008800:c4534577-4534350 [Yersinia enterocolitica subsp. enterocolitica 8081]
MRTVSIFKNGQNRAIRLPKDMNFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Nucleotide

• Length: 228 bp

>AT21948 NC_008800:c4534577-4534350 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGAGAACGGTATCTATTTTCAAAAATGGGCAGAATCGAGCAATTCGTTTGCCAAAAGATATGAATTTTGATGGCGTGAC
CGAGCTGGAAATACTCAGAGACGGTGATAGTATTATTTTACGACCCATACGCCCGACATGGGTATCATTCATGGATGAAG
ATAAGGCAGATGATGATTTTCTTGCCGAAAGACAGGATGTTATCGAAGAAGGGCGCTTCGAGTTATGA

Structures

Toxin

• AlphaFold DB: A1JT39