Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 801233..801890 Replicon chromosome
Accession NZ_CP084825
Organism Klebsiella pneumoniae strain SB617

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM18_RS03980 Protein ID WP_002916310.1
Coordinates 801480..801890 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM18_RS03975 Protein ID WP_002916312.1
Coordinates 801233..801499 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM18_RS03950 (796389) 796389..797822 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LGM18_RS03955 (797941) 797941..798669 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGM18_RS03960 (798719) 798719..799030 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGM18_RS03965 (799194) 799194..799853 + 660 WP_002916317.1 hemolysin III family protein -
LGM18_RS03970 (800004) 800004..800987 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LGM18_RS03975 (801233) 801233..801499 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM18_RS03980 (801480) 801480..801890 + 411 WP_002916310.1 protein YgfX Toxin
LGM18_RS03985 (801897) 801897..802418 - 522 WP_002916308.1 flavodoxin FldB -
LGM18_RS03990 (802519) 802519..803415 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM18_RS03995 (803438) 803438..804151 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM18_RS04000 (804157) 804157..805890 + 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219478 WP_002916310.1 NZ_CP084825:801480-801890 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219478 NZ_CP116477:3161486-3161689 [Pectobacterium sp. A5351]
ATGAAAAAAATTGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACCCTCGAACGCGTTATTGAAAAAAACAA
GTATGAGCTATCCAATGATGAACTGGAGATGTTCTTTTCCGCTGCCGATCATCGTCTGGCAGAACTGACGATGAACAAAC
TCTATGACAAAGTGCCTACTGCGGTATGGCGATACGTCCGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219478 WP_002916312.1 NZ_CP084825:801233-801499 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219478 NZ_CP116477:3161064-3161432 [Pectobacterium sp. A5351]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
AACGTTAGGTGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTACGGTATTAATGATGCTGAGCTGCGGTGCTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References