Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 181455..182125 | Replicon | plasmid pKp_T69_1 |
| Accession | NZ_CP084824 | ||
| Organism | Klebsiella pneumoniae strain T69 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q6U619 |
| Locus tag | LGM19_RS26910 | Protein ID | WP_004213072.1 |
| Coordinates | 181455..181898 (-) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q6U620 |
| Locus tag | LGM19_RS26915 | Protein ID | WP_004213073.1 |
| Coordinates | 181895..182125 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM19_RS26875 (LGM19_26875) | 176866..177141 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
| LGM19_RS26880 (LGM19_26880) | 177204..177695 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
| LGM19_RS26885 (LGM19_26885) | 177744..178664 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
| LGM19_RS26890 (LGM19_26890) | 178755..179158 | + | 404 | Protein_192 | GAF domain-containing protein | - |
| LGM19_RS26895 (LGM19_26895) | 179675..180311 | - | 637 | Protein_193 | mucoid phenotype regulator RmpA2 | - |
| LGM19_RS26900 (LGM19_26900) | 180728..181032 | + | 305 | Protein_194 | transposase | - |
| LGM19_RS26905 (LGM19_26905) | 181055..181306 | - | 252 | WP_186987481.1 | hypothetical protein | - |
| LGM19_RS26910 (LGM19_26910) | 181455..181898 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LGM19_RS26915 (LGM19_26915) | 181895..182125 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LGM19_RS26920 (LGM19_26920) | 182733..183866 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
| LGM19_RS26925 (LGM19_26925) | 183882..184175 | + | 294 | WP_004213076.1 | hypothetical protein | - |
| LGM19_RS26930 (LGM19_26930) | 184165..184371 | - | 207 | WP_004213077.1 | hypothetical protein | - |
| LGM19_RS26935 (LGM19_26935) | 184723..185013 | + | 291 | WP_004213078.1 | hypothetical protein | - |
| LGM19_RS26940 (LGM19_26940) | 185003..185902 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..206626 | 206626 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T219474 WP_004213072.1 NZ_CP084824:c181898-181455 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T219474 NZ_CP116477:952011-952514 [Pectobacterium sp. A5351]
ATGCATCTTGGTTTAACAGGGCTATATCAGCCAAAATGGACGGCACTAATTCAGGAAGAGTGGCAGCGAAATTTGTTGCT
AAATAATGCGGACGTAACGATGGATAAGCTCAGGAACATTGAGCATTTGATGAATAAGGCATTACCCGATGCCAATGTGA
CTGGATTCGAGCAACTTATCCCTGCTCTGGTTTTACCTGATGCGGATGATCGACATGTATTGGCAGCGGCGATACGCGCT
AATGCAGAAGTCATCGTCACTGCGAATCTGAAAGACTTTCCTGCAACGGCACTTTTGGAATTTGGAGTGGAAGCCATGCA
TCCAGACGAATTCATTGCCGATTTATTTGATCTCAATTCTGCTCTGGTGCTTAAAGCGGTTCGCACTTCGCGCACTGCCT
TCAGAAAGCCTCCGTTTGATGTAGACGAATATCTGGATTGTCTCCTGCGTCAGGGGCTACCAATGACGGTAAAAGAACTG
GATGCGTATCGATCACTGATTTAA
ATGCATCTTGGTTTAACAGGGCTATATCAGCCAAAATGGACGGCACTAATTCAGGAAGAGTGGCAGCGAAATTTGTTGCT
AAATAATGCGGACGTAACGATGGATAAGCTCAGGAACATTGAGCATTTGATGAATAAGGCATTACCCGATGCCAATGTGA
CTGGATTCGAGCAACTTATCCCTGCTCTGGTTTTACCTGATGCGGATGATCGACATGTATTGGCAGCGGCGATACGCGCT
AATGCAGAAGTCATCGTCACTGCGAATCTGAAAGACTTTCCTGCAACGGCACTTTTGGAATTTGGAGTGGAAGCCATGCA
TCCAGACGAATTCATTGCCGATTTATTTGATCTCAATTCTGCTCTGGTGCTTAAAGCGGTTCGCACTTCGCGCACTGCCT
TCAGAAAGCCTCCGTTTGATGTAGACGAATATCTGGATTGTCTCCTGCGTCAGGGGCTACCAATGACGGTAAAAGAACTG
GATGCGTATCGATCACTGATTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT219474 WP_004213073.1 NZ_CP084824:c182125-181895 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT219474 NZ_CP116477:951478-951939 [Pectobacterium sp. A5351]
ATGAAAAATACTCCTCTAAATAGTTTGAGCCTTCCGGCTCCAAAAGAAATGGAGGCCGCTATTCGTGGACAAAGGCAGCT
TGCAACCTACCTGTCTACGAAGCTGGAAACACAGGAAATATCGATTCAGGATGCACAAGACATTGCCCAGAAGATCGAGC
TGCCTACCTCGGCACTTACGCTTTTGATGAGCATCCTTGGCGAACTGGCGGCGGGTAATGCTGTCCAGATTGTCCCCGTG
CAGGCTGAGTTAACGACACAAGAAGCGGCAAATATTCTGAATGTTTCACGGCCACATATGGTGAAGCTTTTGGAGGGAGG
CCATCTTCCTTTCCATAAAACAGGTCGTCATCGCCGCGTGCTTTTTGCTGATTTGATGCAATACAAAGAACAGCGTGAAA
ATGAAAGTATGCAAGCCATGCAGGAGTTGACAGACCGAAGTCAGGAACTCGGGTTTTACTAA
ATGAAAAATACTCCTCTAAATAGTTTGAGCCTTCCGGCTCCAAAAGAAATGGAGGCCGCTATTCGTGGACAAAGGCAGCT
TGCAACCTACCTGTCTACGAAGCTGGAAACACAGGAAATATCGATTCAGGATGCACAAGACATTGCCCAGAAGATCGAGC
TGCCTACCTCGGCACTTACGCTTTTGATGAGCATCCTTGGCGAACTGGCGGCGGGTAATGCTGTCCAGATTGTCCCCGTG
CAGGCTGAGTTAACGACACAAGAAGCGGCAAATATTCTGAATGTTTCACGGCCACATATGGTGAAGCTTTTGGAGGGAGG
CCATCTTCCTTTCCATAAAACAGGTCGTCATCGCCGCGTGCTTTTTGCTGATTTGATGCAATACAAAGAACAGCGTGAAA
ATGAAAGTATGCAAGCCATGCAGGAGTTGACAGACCGAAGTCAGGAACTCGGGTTTTACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|