Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5329704..5330361 Replicon chromosome
Accession NZ_CP084823
Organism Klebsiella pneumoniae strain T69

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM19_RS25800 Protein ID WP_002916310.1
Coordinates 5329704..5330114 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM19_RS25805 Protein ID WP_002916312.1
Coordinates 5330095..5330361 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM19_RS25780 (5325704) 5325704..5327437 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
LGM19_RS25785 (5327443) 5327443..5328156 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM19_RS25790 (5328179) 5328179..5329075 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM19_RS25795 (5329176) 5329176..5329697 + 522 WP_002916308.1 flavodoxin FldB -
LGM19_RS25800 (5329704) 5329704..5330114 - 411 WP_002916310.1 protein YgfX Toxin
LGM19_RS25805 (5330095) 5330095..5330361 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM19_RS25810 (5330607) 5330607..5331590 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LGM19_RS25815 (5331689) 5331689..5332348 - 660 WP_002916317.1 hemolysin III family protein -
LGM19_RS25820 (5332512) 5332512..5332823 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGM19_RS25825 (5332873) 5332873..5333601 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGM19_RS25830 (5333720) 5333720..5335153 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219471 WP_002916310.1 NZ_CP084823:c5330114-5329704 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219471 NZ_CP116477:c781819-781523 [Pectobacterium sp. A5351]
ATGACGAGGAAGATTGAGCGTTCAACAGAGTTTAAAAAAGACTACAAGCGCGAAAAGAAAGGGCGGCACTGTAGAACCGT
TGAGGCTGATTTGTTGGTACTATTAAATATACTGGCAAATGATTTACCCATATCGGCTAACTACGTTGACCATCCATTGA
GAGGAAATTGGCGTAGCTTCCGAGATTGTCATTTATATCCAGATTTAATTTTAATTTATAAAAAGATCAATAATGAAGAA
GACGACTCTGGTATTTTAAAGTTGGCTCGCCTTGGTTCACATAGTGAATTATTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219471 WP_002916312.1 NZ_CP084823:c5330361-5330095 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219471 NZ_CP116477:c782084-781803 [Pectobacterium sp. A5351]
ATGGCGACAGAAACTTATGTAAGGGCGAAGATTGACCCTAAAACAAAGGCGCTTGCAACGGTTGCGCTTGAATCTATGGG
GTTAACGGTGAGTGATGCTATTCGATTATTAATGGTGCAAGTTGCAGAGAAAAATGAGCTACCTTTTAAAGTTAAGGGGG
CTAATTATATAAATGCACGACGCACGAAGGCTGCAATTAATCAGCTTGAACATGGAAGGGGGAAGCAGTTTGATAATGTT
GCGGCTCTGATGGATGATCTGAATAATGACGAGGAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References