Detailed information of TA system TA021947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4189426..4191055
• Replicon: chromosome
• Accession: NC_008800
• Organism: Yersinia enterocolitica subsp. enterocolitica 8081

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A8B6KYH1
• Locus tag: YE_RS19255
• Protein ID: WP_005174384.1
• Coordinates: 4189727..4191055 (+)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: YE_RS19250
• Protein ID: WP_004391839.1
• Coordinates: 4189426..4189725 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE_RS19235 (YE3839)	4184781..4186430	-	1650	WP_005174376.1	Na+/H+ antiporter	-
YE_RS19240 (YE3840)	4186646..4188013	-	1368	WP_042661540.1	NCS2 family permease	-
YE_RS19245 (YE3841)	4188489..4189160	-	672	WP_011817296.1	glutathione S-transferase	-
YE_RS19250 (YE3842)	4189426..4189725	+	300	WP_004391839.1	helix-turn-helix transcriptional regulator	Antitoxin
YE_RS19255 (YE3843)	4189727..4191055	+	1329	WP_005174384.1	type II toxin-antitoxin system HipA family toxin	Toxin
YE_RS19260 (YE3844)	4191120..4191671	-	552	WP_005174387.1	single-stranded DNA-binding protein SSB1	-
YE_RS19265 (YE3845)	4192071..4194902	+	2832	WP_005174389.1	excinuclease ABC subunit UvrA	-
YE_RS19270 (YE3846)	4194961..4195314	-	354	WP_005165225.1	MmcQ/YjbR family DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (155-405)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-66)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49856.68 Da
• Isoelectric Point: 6.7708

>T21947 WP_005174384.1 NC_008800:4189727-4191055 [Yersinia enterocolitica subsp. enterocolitica 8081]
MARRIQRLNIWMNGQHVGYWEKNRGEESLTYAQEWLANEQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATKYHADSINPFDLLFELGRDCVGAIQLLTDDAPPSDLFSIQQQPLTESDVARILRNSLSDNAFVRPEHDEDLRLSIAGA
QEKTALLFHDNRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVASCEIGQFEDQKALIVERF
DRRLSNDSRWIVRLPQEDMCQATGTSPLKKYQTDGGPGITTIMEILSGSDNASEDRKVFFKAQIIFWLLAATDGHAKNFS
ITHLPANHYHLTPLYDVLSTHPIIGAGRNQIAAQKTKLAMAVRGSKNYYLINQIQRRHWRKQAEIVGLGAAQADSIIDEI
ITATPRVITQIQARLPANFPTDLAESILTGLHRQCEKIAAMP

Nucleotide

• Length: 1329 bp

>T21947 NC_008800:4189727-4191055 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGGCTCGTCGCATTCAACGGCTCAATATCTGGATGAATGGTCAACATGTTGGCTATTGGGAAAAAAATCGAGGTGAAGA
ATCACTGACTTATGCCCAGGAATGGCTAGCAAACGAACAAGGCCGCCCGCTGTCATTATCATTGCCTTTTACGGCCAATA
ATCAGGTTTATCGAGGCAATATTGTCCGGGACTATTTTGATAATTTATTACCCGATAGCGATGATATCCGGCGACGTCTG
GCAACTAAATATCACGCTGACAGCATTAACCCTTTCGATCTACTGTTTGAATTAGGAAGAGATTGTGTCGGTGCAATACA
ATTGCTAACTGATGATGCTCCTCCCTCTGATCTATTCTCAATTCAACAACAACCACTAACAGAAAGCGATGTGGCTCGCA
TCCTACGAAACTCATTATCTGACAATGCATTTGTGCGCCCTGAACACGATGAGGATCTCAGATTGTCTATCGCAGGGGCA
CAAGAAAAAACAGCTCTTTTGTTTCACGACAACCGATGGTGCCTCCCATTAGGCAGCACTCCCACCACCCATATCTTCAA
ACTTCCGTTGGGCTTAGTCGGCAATATGCAAGCTGATATGAGGACCTCGGTTGAAAATGAATGGCTGTGTGCAAAAATTC
TGGCAAGTTATAACTTACCGGTTGCCAGTTGTGAAATTGGCCAATTTGAAGACCAAAAAGCATTGATTGTTGAACGTTTT
GACCGACGACTATCGAATGATAGCCGCTGGATTGTCAGGTTACCGCAAGAGGATATGTGCCAAGCGACTGGGACTTCCCC
CTTAAAAAAATATCAAACGGATGGTGGCCCCGGTATTACAACCATCATGGAGATTTTAAGTGGCTCGGATAATGCCAGTG
AAGACAGAAAAGTCTTCTTTAAAGCACAAATTATTTTCTGGTTACTGGCAGCAACGGATGGACATGCAAAAAATTTCAGC
ATTACACATCTGCCCGCCAACCATTACCATCTCACCCCACTTTATGATGTGCTATCAACCCATCCGATTATCGGGGCGGG
CCGTAATCAAATTGCGGCCCAGAAAACCAAGTTAGCGATGGCGGTGCGAGGGAGTAAAAATTACTATTTAATTAACCAGA
TACAGCGACGCCATTGGCGAAAACAGGCCGAGATTGTTGGGCTGGGAGCTGCTCAGGCTGACAGTATTATTGATGAAATT
ATTACCGCTACCCCGAGAGTCATCACACAAATACAAGCTCGACTCCCCGCTAATTTTCCAACTGATTTAGCAGAAAGTAT
CCTCACAGGTCTTCATCGGCAGTGCGAAAAAATAGCGGCAATGCCCTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11081.73 Da
• Isoelectric Point: 8.5374

>AT21947 WP_004391839.1 NC_008800:4189426-4189725 [Yersinia enterocolitica subsp. enterocolitica 8081]
MDYPIKILSQLRPTLIGFRKNKGLTQASLAQLLGITQQSYAKLEADPASASVERLFKVLQLLDVELILGEKKNASAHPNK
THQPEQSQTIDLPSKQEDW

Nucleotide

• Length: 300 bp

>AT21947 NC_008800:4189426-4189725 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGGACTATCCCATTAAAATTTTGAGTCAATTACGCCCTACGTTGATTGGTTTTCGAAAAAATAAAGGGCTGACTCAGGC
CAGCCTGGCACAACTGTTAGGTATCACCCAGCAGTCCTATGCAAAGCTTGAAGCTGATCCCGCCTCGGCCAGTGTTGAAC
GGCTTTTTAAAGTATTACAACTTTTAGACGTAGAACTGATCCTTGGTGAGAAAAAAAACGCCAGCGCGCATCCCAATAAA
ACCCACCAGCCAGAACAAAGCCAGACGATAGATTTACCGTCAAAACAAGAGGATTGGTAA

Structures

Toxin

• AlphaFold DB: A0A8B6KYH1