Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 2066652..2067271 | Replicon | chromosome |
Accession | NZ_CP084823 | ||
Organism | Klebsiella pneumoniae strain T69 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | LGM19_RS09925 | Protein ID | WP_002892050.1 |
Coordinates | 2066652..2066870 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | LGM19_RS09930 | Protein ID | WP_002892066.1 |
Coordinates | 2066897..2067271 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LGM19_RS09890 (2062699) | 2062699..2062962 | + | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
LGM19_RS09895 (2062962) | 2062962..2063102 | + | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
LGM19_RS09900 (2063099) | 2063099..2063797 | - | 699 | WP_002892021.1 | GNAT family protein | - |
LGM19_RS09905 (2063898) | 2063898..2065349 | + | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
LGM19_RS09910 (2065324) | 2065324..2065794 | - | 471 | WP_002892026.1 | YlaC family protein | - |
LGM19_RS09915 (2065815) | 2065815..2065955 | + | 141 | WP_004147370.1 | hypothetical protein | - |
LGM19_RS09920 (2065927) | 2065927..2066493 | - | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
LGM19_RS09925 (2066652) | 2066652..2066870 | - | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
LGM19_RS09930 (2066897) | 2066897..2067271 | - | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
LGM19_RS09935 (2067757) | 2067757..2070903 | - | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
LGM19_RS09940 (2070926) | 2070926..2072119 | - | 1194 | WP_004177236.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T219461 WP_002892050.1 NZ_CP084823:c2066870-2066652 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T219461 NZ_CP116458:c1862791-1862369 [Acidithiobacillus ferriphilus]
GTGAGATACCTCCTGGATACCTGCGTTCTGTCAGAGTTGGTCAAAAAGCATCCTGATCCTCGGGTCGTAACATGGGTAGA
CGCACGGGAGGCTGTGGGGTTTCTTAGTGTGCTCACACTGGGAGAGCTCCAAAAAGGCGTTGCCAAACTTGTTGACGGCG
ATAAGCGATCAATGCTGCAGGATTGGATAGACGTTGATCTGCGAGGTCGTTTTGTCGGACGTATTCTTCCTGTTAACGAG
CATATCGCCAGTGCATGGGGAGGTATAACAGGTGCCGCAGAACAACGCGGAGAGAAGTTGCCAGCGATAGATAGCTTGCT
GGCAGCCACGGCGCTGGTTCACCATCTCACAGTGGCCACGCGGAATATTGTTGATTTACAGCGATGCCAAGTTCCGGTGG
TCGATCCCTGGGATCAAACATAG
GTGAGATACCTCCTGGATACCTGCGTTCTGTCAGAGTTGGTCAAAAAGCATCCTGATCCTCGGGTCGTAACATGGGTAGA
CGCACGGGAGGCTGTGGGGTTTCTTAGTGTGCTCACACTGGGAGAGCTCCAAAAAGGCGTTGCCAAACTTGTTGACGGCG
ATAAGCGATCAATGCTGCAGGATTGGATAGACGTTGATCTGCGAGGTCGTTTTGTCGGACGTATTCTTCCTGTTAACGAG
CATATCGCCAGTGCATGGGGAGGTATAACAGGTGCCGCAGAACAACGCGGAGAGAAGTTGCCAGCGATAGATAGCTTGCT
GGCAGCCACGGCGCTGGTTCACCATCTCACAGTGGCCACGCGGAATATTGTTGATTTACAGCGATGCCAAGTTCCGGTGG
TCGATCCCTGGGATCAAACATAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT219461 WP_002892066.1 NZ_CP084823:c2067271-2066897 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT219461 NZ_CP116458:c1863042-1862788 [Acidithiobacillus ferriphilus]
ATGAATACTCAGTGGCCTTTACAGGAGGCGCGCAATCATTTGAGCGATGTCGTGAAGCGTGCCCGCAATGATGGTCCGCA
AACCATTACCTTACATGGTGAGCCCGCGGTTGTAGTGCTCTCCGTAGAACAGTTTCGGACGTTGACACGGCCGAACCAGA
CGTTATCCGAATTCCTCGCGAACTCTCCACTGCGAGGGCTCGATCTGGAAGTCGAACGAGATCATCACGATGTGGGGCGC
GACGTCAGCCTGTGA
ATGAATACTCAGTGGCCTTTACAGGAGGCGCGCAATCATTTGAGCGATGTCGTGAAGCGTGCCCGCAATGATGGTCCGCA
AACCATTACCTTACATGGTGAGCCCGCGGTTGTAGTGCTCTCCGTAGAACAGTTTCGGACGTTGACACGGCCGAACCAGA
CGTTATCCGAATTCCTCGCGAACTCTCCACTGCGAGGGCTCGATCTGGAAGTCGAACGAGATCATCACGATGTGGGGCGC
GACGTCAGCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |