Detailed information of TA system TA021946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 3792208..3792761
• Replicon: chromosome
• Accession: NC_008800
• Organism: Yersinia enterocolitica subsp. enterocolitica 8081

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A1JQ03
• Locus tag: YE_RS17430
• Protein ID: WP_011817079.1
• Coordinates: 3792208..3792522 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A1JQ04
• Locus tag: YE_RS17435
• Protein ID: WP_011817080.1
• Coordinates: 3792525..3792761 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE_RS17405 (YE3475)	3787828..3788253	+	426	WP_011817075.1	glutaredoxin-dependent arsenate reductase	-
YE_RS17410 (YE3476)	3788299..3789492	-	1194	WP_011816240.1	IS4 family transposase	-
YE_RS17415 (YE3477)	3789694..3790404	-	711	WP_011817076.1	arsenical resistance protein ArsH	-
YE_RS17420 (YE3478)	3790536..3790829	-	294	WP_011817077.1	metalloregulator ArsR/SmtB family transcription factor	-
YE_RS17425 (YE3479)	3790936..3792069	+	1134	WP_011817078.1	permease	-
YE_RS17430 (YE3480)	3792208..3792522	-	315	WP_011817079.1	CcdB family protein	Toxin
YE_RS17435 (YE3481)	3792525..3792761	-	237	WP_011817080.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
YE_RS17440 (YE3482)	3793238..3796042	-	2805	WP_080326924.1	conjugative transfer ATPase	-
YE_RS17445 (YE3483)	3796042..3796443	-	402	WP_042661505.1	TIGR03751 family conjugal transfer lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	pilW / pilV / pilU / pilS / pilR / pilQ / pilP / pilO / pilN / pilM / pilL	3761949..3828088	66139
	-	flank	IS/Tn	-	-	3788299..3789492	1193

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-102)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11582.50 Da
• Isoelectric Point: 5.8036

>T21946 WP_011817079.1 NC_008800:c3792522-3792208 [Yersinia enterocolitica subsp. enterocolitica 8081]
MQFTVYSNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGSTRPERLVPLVRLTDDKEYAVMTHEMASIPARSLG
AVFCDASPYRIEVKAAIDFLLDSI

Nucleotide

• Length: 315 bp

>T21946 NC_008800:c3792522-3792208 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGCAGTTCACTGTATACAGTAACACTGGGAAGAGCGCTGTCTATCCCTTGCTGCTTGATGTAACCAGCGACATTATCGG
CCAGTTGAATCGTAGGATTGTAATCCCGCTGCTGCCTGTTGAAAAGTACCCAGGCAGTACACGTCCGGAACGACTGGTTC
CGCTTGTCAGACTGACCGACGATAAAGAATATGCAGTTATGACGCATGAAATGGCGAGTATTCCCGCCCGTTCTTTGGGG
GCTGTGTTCTGCGATGCTTCCCCTTATCGTATCGAAGTTAAAGCTGCGATTGATTTTCTCCTCGATAGTATTTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8892.87 Da
• Isoelectric Point: 5.6870

>AT21946 WP_011817080.1 NC_008800:c3792761-3792525 [Yersinia enterocolitica subsp. enterocolitica 8081]
MSTTQRATQSVTMAVERALLSRAREAGINLSATLTAALDAELRQYEAKKWQEENNKALEALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT21946 NC_008800:c3792761-3792525 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGTCTACAACACAACGAGCAACACAAAGCGTTACCATGGCCGTAGAACGAGCTTTACTCAGCCGGGCCCGTGAAGCTGG
AATCAATCTCAGTGCCACCCTGACCGCAGCCCTTGACGCTGAACTACGCCAGTATGAAGCGAAAAAATGGCAGGAGGAAA
ACAACAAAGCACTGGAAGCACTTAACCGTTTTCACGATGAACATGGTTGTTTCAGTGATGAATACAGGACATTTTAA

Structures

Toxin

• AlphaFold DB: A1JQ03

Antitoxin

• AlphaFold DB: A1JQ04