Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 568389..569128 Replicon chromosome
Accession NZ_CP084823
Organism Klebsiella pneumoniae strain T69

Toxin (Protein)


Gene name tacT Uniprot ID A0A4U9WP91
Locus tag LGM19_RS02805 Protein ID WP_004901283.1
Coordinates 568389..568874 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LGM19_RS02810 Protein ID WP_003026799.1
Coordinates 568862..569128 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM19_RS02780 (564018) 564018..564308 + 291 WP_002921931.1 HTH-type transcriptional regulator -
LGM19_RS02785 (564560) 564560..564772 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LGM19_RS02790 (564871) 564871..566490 - 1620 WP_004901278.1 ATP-binding cassette domain-containing protein -
LGM19_RS02795 (566792) 566792..566944 - 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
LGM19_RS02800 (567018) 567018..568064 + 1047 WP_004173931.1 IS481-like element ISKpn28 family transposase -
LGM19_RS02805 (568389) 568389..568874 - 486 WP_004901283.1 GNAT family N-acetyltransferase Toxin
LGM19_RS02810 (568862) 568862..569128 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LGM19_RS02815 (569261) 569261..569689 - 429 WP_004901287.1 GFA family protein -
LGM19_RS02825 (571555) 571555..573624 - 2070 WP_004901297.1 glycine--tRNA ligase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 567018..570615 3597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17594.32 Da        Isoelectric Point: 10.1788

>T219457 WP_004901283.1 NZ_CP084823:c568874-568389 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLNQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

>T219457 NZ_CP116458:638344-638850 [Acidithiobacillus ferriphilus]
ATGAACTTGGGCAAGCCAGATCCTTTGGTCATTCATGGCTGGACGGTTTTTGTTCACCCCTTGTTCCTGGCTCAGCTTGA
AGCTCTGGCCCGGCAGGTCGGGGCCTTCAAGCAAAAAGATCCGGTCGGGTACGTGAAGAAGAACGCCAGCAAGCGATTGG
CGGCGATCACCAAACTCGCGTTCGATGTCATTCCACAAAATCCGGCGCGGCCCGAATACCGGCAAGGCAACACGCTCGGT
GACGAGTACAAGCACTGGTTTCGAGCCAGGTTCTTCCAGCAATACCGGCTGTTCTTCCGTTACCACGCATCAAGCAAGGT
GATCGTGTTCGTGTGGGTCAACGACGAGGACACCAAGCGCGCCTATGAGAGCAGTGATGACGCCTATCGGGTGTTCCGCA
AGATGCTGGAAAGCGGCCATCCTCCGGATGACTGGAAACATCTGCTGGCGGAGGCCCGGGCCGAGAGGCAACGCTTGCAG
CCGTTCACCTCCGCCATCACGCCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT219457 WP_003026799.1 NZ_CP084823:c569128-568862 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT219457 NZ_CP116458:638018-638347 [Acidithiobacillus ferriphilus]
ATGCCCACTACCCTCGAAGTCGAATCCACACTCACCGACCGCTACCAGACCACGGTGCCGGAAACTGTCCGCCGCGCCCT
CAAGTTGGGCAAGCGCGACAAGATTCACTACACGATCCGCCTCAGCGGCGAGGTCGTGCTGACGCGCGCCGAGGTCGGCG
AAGACGACGATCCGGTGCTTGGCCAGTTCCTGGACTTCCTGGCTCACGACATCGCCAGCCACCCAGAGCGCCTGCAGGTC
GTGGACGTTGGCCTTGTCCGCCGACTCCAGTCACTGGTCGGCGGCATTGAAGTCAATCTCGACGCCGCCCTGTCGGCAGA
CGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U9WP91

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References