Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 18749..19326 | Replicon | plasmid pKqq_18A069_2 |
| Accession | NZ_CP084820 | ||
| Organism | Klebsiella quasipneumoniae subsp. quasipneumoniae strain 18A069 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | A0A7G3NNX6 |
| Locus tag | LGM21_RS26650 | Protein ID | WP_059065587.1 |
| Coordinates | 18749..19081 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | A0A7G3NP82 |
| Locus tag | LGM21_RS26655 | Protein ID | WP_032454911.1 |
| Coordinates | 19081..19326 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM21_RS26600 (LGM21_26600) | 13895..14185 | + | 291 | WP_001247892.1 | nucleotidyltransferase | - |
| LGM21_RS26605 (LGM21_26605) | 14182..14583 | + | 402 | WP_001293886.1 | DUF86 domain-containing protein | - |
| LGM21_RS26610 (LGM21_26610) | 14573..14929 | + | 357 | WP_032454986.1 | cupin domain-containing protein | - |
| LGM21_RS26615 (LGM21_26615) | 15184..15510 | + | 327 | WP_003100858.1 | hypothetical protein | - |
| LGM21_RS26620 (LGM21_26620) | 15507..16007 | + | 501 | WP_003100856.1 | hypothetical protein | - |
| LGM21_RS26625 (LGM21_26625) | 16004..16375 | + | 372 | WP_003100853.1 | hypothetical protein | - |
| LGM21_RS26630 (LGM21_26630) | 16369..16926 | + | 558 | WP_003100847.1 | recombinase family protein | - |
| LGM21_RS26635 (LGM21_26635) | 17005..18009 | + | 1005 | WP_000427614.1 | IS110-like element IS5075 family transposase | - |
| LGM21_RS26640 (LGM21_26640) | 18286..18483 | + | 198 | Protein_28 | IS3 family transposase | - |
| LGM21_RS26645 (LGM21_26645) | 18480..18674 | - | 195 | WP_071997591.1 | hypothetical protein | - |
| LGM21_RS26650 (LGM21_26650) | 18749..19081 | - | 333 | WP_059065587.1 | endoribonuclease MazF | Toxin |
| LGM21_RS26655 (LGM21_26655) | 19081..19326 | - | 246 | WP_032454911.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| LGM21_RS26660 (LGM21_26660) | 20039..20425 | + | 387 | Protein_32 | Tn3 family transposase | - |
| LGM21_RS26665 (LGM21_26665) | 20449..21078 | + | 630 | Protein_33 | IS110 family transposase | - |
| LGM21_RS26670 (LGM21_26670) | 21107..22699 | - | 1593 | WP_032454909.1 | IS66-like element ISKox1 family transposase | - |
| LGM21_RS26675 (LGM21_26675) | 22730..23080 | - | 351 | WP_004189161.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| LGM21_RS26680 (LGM21_26680) | 23077..23517 | - | 441 | WP_004189163.1 | transposase | - |
| LGM21_RS26685 (LGM21_26685) | 23610..24005 | + | 396 | Protein_37 | IS110 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | sul1 / qacE / ant(3'')-Ia | - | 1..75062 | 75062 | |
| - | inside | IScluster/Tn | sul1 / qacE / ant(3'')-Ia | - | 1142..23517 | 22375 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11991.87 Da Isoelectric Point: 7.7494
>T219454 WP_059065587.1 NZ_CP084820:c19081-18749 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MVSRFVPDAGDLIWINFDPVEGHEQGGHRPAVVLSPFAYNNKTGLLLCVPCTTKVKGYPFEVELPGERDGVALADQITCV
DWRARKVEKKGKVATGELSEIRAKAKALIG
MVSRFVPDAGDLIWINFDPVEGHEQGGHRPAVVLSPFAYNNKTGLLLCVPCTTKVKGYPFEVELPGERDGVALADQITCV
DWRARKVEKKGKVATGELSEIRAKAKALIG
Download Length: 333 bp
>T219454 NZ_CP116458:218416-218817 [Acidithiobacillus ferriphilus]
GTGATCAACTACCTGCTGGATACCAACATCTGCATTTTCACCATCAAATGCAAACCGCCAGAGATTCGGGAGCAATTTCG
TCGATACCATGGGCAGATGGCCATCAGCGCGGTCACCTTGATGGAGTTGATCTATGGTGCGGAGAAGTCACAAGCACCAG
AGCGCAATCTGGCGGAGATCGAAGGATTCGCGGCGAGATTGGAGCTTCTCGAATACGGGAGTGAGGCCGCGAAGCATACC
GGGCAGATCCGCGCCGAACTGGCCAAGGTTGGTAAGCCCATCGGGCCATATGACCAGATGATCGCGGGCCACGCCAGAAG
CCGCGGTTTGATCGTCGTGACCAACAACCTGCGGAAATTCGAGCGGGTTCCCGGATTGCGCGTCGTGGATTGGGTGCAAT
GA
GTGATCAACTACCTGCTGGATACCAACATCTGCATTTTCACCATCAAATGCAAACCGCCAGAGATTCGGGAGCAATTTCG
TCGATACCATGGGCAGATGGCCATCAGCGCGGTCACCTTGATGGAGTTGATCTATGGTGCGGAGAAGTCACAAGCACCAG
AGCGCAATCTGGCGGAGATCGAAGGATTCGCGGCGAGATTGGAGCTTCTCGAATACGGGAGTGAGGCCGCGAAGCATACC
GGGCAGATCCGCGCCGAACTGGCCAAGGTTGGTAAGCCCATCGGGCCATATGACCAGATGATCGCGGGCCACGCCAGAAG
CCGCGGTTTGATCGTCGTGACCAACAACCTGCGGAAATTCGAGCGGGTTCCCGGATTGCGCGTCGTGGATTGGGTGCAAT
GA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8881.21 Da Isoelectric Point: 5.7996
>AT219454 WP_032454911.1 NZ_CP084820:c19326-19081 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MSQATFKKWGNQAGIRFPAAVMKAAALNVDDTVDIEVQEGRIVLIPTKEKTYSLDALLSGITEENMHNKADFGKPTGKEM
L
MSQATFKKWGNQAGIRFPAAVMKAAALNVDDTVDIEVQEGRIVLIPTKEKTYSLDALLSGITEENMHNKADFGKPTGKEM
L
Download Length: 246 bp
>AT219454 NZ_CP116458:218189-218419 [Acidithiobacillus ferriphilus]
ATGGAAAAGGCCACTATTTTTCTAAGTAACCGCAGCCAGGCGGTGCGTTTACCCAAAGCCATCGCTTTTCCCGCCGATGT
GAAGCGCGTGGAAGTGCTCGTCATGGGCCGGGCGAGGATGCTGATTCCCGCAGGAGAATCCTGGGACAGCTGGTTCGATG
GCGAAGGGGTCAGCGCGGATTTTATGGAACATCGGGAGCAACCTGCCGATCAGGTCCGGGAGTCCCTGTGA
ATGGAAAAGGCCACTATTTTTCTAAGTAACCGCAGCCAGGCGGTGCGTTTACCCAAAGCCATCGCTTTTCCCGCCGATGT
GAAGCGCGTGGAAGTGCTCGTCATGGGCCGGGCGAGGATGCTGATTCCCGCAGGAGAATCCTGGGACAGCTGGTTCGATG
GCGAAGGGGTCAGCGCGGATTTTATGGAACATCGGGAGCAACCTGCCGATCAGGTCCGGGAGTCCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7G3NNX6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7G3NP82 |