Detailed information of TA system TA219452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4773103..4773574
• Replicon: chromosome
• Accession: NZ_CP084818
• Organism: Klebsiella quasipneumoniae subsp. quasipneumoniae strain 18A069

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGM21_RS23335
• Protein ID: WP_023291758.1
• Coordinates: 4773103..4773342 (-)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: LGM21_RS23340
• Protein ID: WP_023291757.1
• Coordinates: 4773332..4773574 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM21_RS23325 (4770056)	4770056..4772194	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
LGM21_RS23330 (4772590)	4772590..4773054	+	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LGM21_RS23335 (4773103)	4773103..4773342	-	240	WP_023291758.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGM21_RS23340 (4773332)	4773332..4773574	-	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LGM21_RS23345 (4773652)	4773652..4775562	-	1911	WP_032454658.1	PRD domain-containing protein	-
LGM21_RS23350 (4775585)	4775585..4776736	-	1152	WP_032454657.1	lactonase family protein	-
LGM21_RS23355 (4776803)	4776803..4777543	-	741	WP_032454656.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-79)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9162.72 Da
• Isoelectric Point: 10.1315

>T219452 WP_023291758.1 NZ_CP084818:c4773342-4773103 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIG

Nucleotide

• Length: 240 bp

>T219452 NZ_CP116458:50221-50472 [Acidithiobacillus ferriphilus]
ATGGATGCGATTACCTATACCACCGTTCGTGCAAACCTCGCCAGCGCCATGGACCGCGTTTGCGACGACCACGAACCCTT
GATCATTACCCGCAATGGCGAACAGTCCGTCGTGATGCTCTCGCTCGAAGACTACAAGGCGCTGGAGGAAACCGCCTACC
TCTTGCGTACCCCCGCCAACGCCAAGCGCCTTCTCGCTGCCGTCGCACAACTGAACGCCGGTAAAGGTGTTGAGCGGAAG
CTGGCGAAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT219452 WP_023291757.1 NZ_CP084818:c4773574-4773332 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT219452 NZ_CP116458:50469-50723 [Acidithiobacillus ferriphilus]
GTGAGGCTGATCTTCTCTGACGATGCATGGGAAGACTACCTATATTGGCAGAAGCAAGACAAGCGCATGGTCGAGCGAAT
CAATAAGCTGATACGTGAGACACAGCGTGAACCCTTCGCTGGAGTTGGCAAACCCGAAGCACTGAAGCATGCTCTTTCAG
GATTTTGGTCACGCCGTATTACAGATGAGCATCGCATGGTGTATCGAATAGAAGGTGATGCATTGATGATTGCTCAGTTG
CGTTTCCACTACTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86