Detailed information of TA system TA219451

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4695234..4696017
• Replicon: chromosome
• Accession: NZ_CP084818
• Organism: Klebsiella quasipneumoniae subsp. quasipneumoniae strain 18A069

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: LGM21_RS23005
• Protein ID: WP_168381062.1
• Coordinates: 4695234..4695602 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: LGM21_RS23010
• Protein ID: WP_032454704.1
• Coordinates: 4695658..4696017 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM21_RS22990 (4691276)	4691276..4692070	-	795	WP_032454709.1	hypothetical protein	-
LGM21_RS22995 (4692303)	4692303..4693100	-	798	WP_077253971.1	helix-turn-helix domain-containing protein	-
LGM21_RS23000 (4693706)	4693706..4694695	+	990	WP_032454707.1	glycosyltransferase	-
LGM21_RS23005 (4695234)	4695234..4695602	-	369	WP_168381062.1	TA system toxin CbtA family protein	Toxin
LGM21_RS23010 (4695658)	4695658..4696017	-	360	WP_032454704.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LGM21_RS23015 (4696040)	4696040..4696261	-	222	WP_032454703.1	DUF987 domain-containing protein	-
LGM21_RS23020 (4696275)	4696275..4696757	-	483	WP_032454702.1	DNA repair protein RadC	-
LGM21_RS23025 (4696754)	4696754..4696987	-	234	WP_032454700.1	hypothetical protein	-
LGM21_RS23030 (4696998)	4696998..4697477	-	480	WP_032454699.1	antirestriction protein	-
LGM21_RS23035 (4697556)	4697556..4698377	-	822	WP_032454698.1	DUF932 domain-containing protein	-
LGM21_RS23040 (4698488)	4698488..4698700	-	213	WP_032454697.1	hypothetical protein	-
LGM21_RS23045 (4698781)	4698781..4699140	-	360	WP_032454696.1	hypothetical protein	-
LGM21_RS23050 (4699195)	4699195..4699605	-	411	WP_050442673.1	hypothetical protein	-
LGM21_RS23055 (4699713)	4699713..4700390	-	678	WP_032454695.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4691276..4722956	31680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (7-110)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13678.52 Da
• Isoelectric Point: 8.9064

>T219451 WP_168381062.1 NZ_CP084818:c4695602-4695234 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
IQSLPPQRAASSRLSSVEIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNSIVEKYDLVRTDRHGFSV
KEQSPFIGSIDMLRARKATRLMPRKGYQTVTDITSGRSSEGK

Nucleotide

• Length: 369 bp

>T219451 NZ_CP116457:1617923-1618258 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13367.44 Da
• Isoelectric Point: 7.0265

>AT219451 WP_032454704.1 NZ_CP084818:c4696017-4695658 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MQKTTSVINHNIAEPWWGLKRNITPCFGARLVQEGNHLHYLADRANITGTFNDADLRHLDQAFPVLMKQMELMLTSNELT
PHIQRCITLHAKGLICEADTLGSCGYLYIVIYPTSAITA

Nucleotide

• Length: 360 bp

>AT219451 NZ_CP116457:1617646-1617933 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA