Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Hha-TomB/- |
| Location | 4032448..4033067 | Replicon | chromosome |
| Accession | NZ_CP084818 | ||
| Organism | Klebsiella quasipneumoniae subsp. quasipneumoniae strain 18A069 | ||
Toxin (Protein)
| Gene name | Hha | Uniprot ID | R8WYV2 |
| Locus tag | LGM21_RS19845 | Protein ID | WP_002892050.1 |
| Coordinates | 4032849..4033067 (+) | Length | 73 a.a. |
Antitoxin (Protein)
| Gene name | TomB | Uniprot ID | J2DPF6 |
| Locus tag | LGM21_RS19840 | Protein ID | WP_002892066.1 |
| Coordinates | 4032448..4032822 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM21_RS19830 (4027598) | 4027598..4028791 | + | 1194 | WP_023288645.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
| LGM21_RS19835 (4028814) | 4028814..4031960 | + | 3147 | WP_023288644.1 | multidrug efflux RND transporter permease subunit AcrB | - |
| LGM21_RS19840 (4032448) | 4032448..4032822 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
| LGM21_RS19845 (4032849) | 4032849..4033067 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
| LGM21_RS19850 (4033226) | 4033226..4033792 | + | 567 | WP_032454010.1 | maltose O-acetyltransferase | - |
| LGM21_RS19855 (4033764) | 4033764..4033895 | - | 132 | WP_032428629.1 | hypothetical protein | - |
| LGM21_RS19860 (4033929) | 4033929..4034399 | + | 471 | WP_023288642.1 | YlaC family protein | - |
| LGM21_RS19865 (4034368) | 4034368..4035825 | - | 1458 | WP_136071291.1 | PLP-dependent aminotransferase family protein | - |
| LGM21_RS19870 (4035926) | 4035926..4036624 | + | 699 | WP_032453932.1 | GNAT family protein | - |
| LGM21_RS19875 (4036621) | 4036621..4036761 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
| LGM21_RS19880 (4036761) | 4036761..4037024 | - | 264 | WP_004204754.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T219450 WP_002892050.1 NZ_CP084818:4032849-4033067 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T219450 NZ_CP116427:87087-87662 [Sulfitobacter faviae]
ATGAGCCGACACGCTGATCGGTTCACGGCGCTCCTCGATGCCTGCGTCCTGGGCGGAGCGCTTCGCAGAAACATGCTCCT
GAGCCTGGCCGAGGCTGGTTTGTTCCGGCCTCGGTGGAGCAGTCGCATCCTTGACGAGACTCAGAAAGCGATCACCCAGA
TCACCAAGGGCGAAACCGATGGGTCCCGGCAAAGGGCGGCAATCGAGGCAGCATTCCCTGAAGCTCTGGTGACTGGTTAT
GAGATCTTCGAAGACAAGCTCGCGTTACCCGACCCCAACGACAACCACGTGCTGGCAGCGGCCATCGCGACGTCTGCTTC
AGTCATCGTGACGGACAATCTTGCCGACTTTCCTTCCGCGGTTCTGGACCCGCACTCCATCCAGGCGATTTCCGCCGACG
ACTTCATCGCCGATACAATCGAGTTGGATCCCTCCGAGGCCATAATGGCCCTGCGCCGGATGAGGGAGCGCTTCAAGAAT
CCGGCGCTCGATGTCGCGACATTGATCCACAAGTCCGAAGCGCAGGGCTTGTTGCAGGTCGCAACCTTCATGGACGAGTA
CCAGTCGTTCTTGTGA
ATGAGCCGACACGCTGATCGGTTCACGGCGCTCCTCGATGCCTGCGTCCTGGGCGGAGCGCTTCGCAGAAACATGCTCCT
GAGCCTGGCCGAGGCTGGTTTGTTCCGGCCTCGGTGGAGCAGTCGCATCCTTGACGAGACTCAGAAAGCGATCACCCAGA
TCACCAAGGGCGAAACCGATGGGTCCCGGCAAAGGGCGGCAATCGAGGCAGCATTCCCTGAAGCTCTGGTGACTGGTTAT
GAGATCTTCGAAGACAAGCTCGCGTTACCCGACCCCAACGACAACCACGTGCTGGCAGCGGCCATCGCGACGTCTGCTTC
AGTCATCGTGACGGACAATCTTGCCGACTTTCCTTCCGCGGTTCTGGACCCGCACTCCATCCAGGCGATTTCCGCCGACG
ACTTCATCGCCGATACAATCGAGTTGGATCCCTCCGAGGCCATAATGGCCCTGCGCCGGATGAGGGAGCGCTTCAAGAAT
CCGGCGCTCGATGTCGCGACATTGATCCACAAGTCCGAAGCGCAGGGCTTGTTGCAGGTCGCAACCTTCATGGACGAGTA
CCAGTCGTTCTTGTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT219450 WP_002892066.1 NZ_CP084818:4032448-4032822 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT219450 NZ_CP116427:86626-87090 [Sulfitobacter faviae]
ATGAACGCCCTCAGAAAAGAGGCGTTCTTTGATCGTTTGCCCGACGAGGTAGAGATCAAGAACGCCGAACAACTCAGAAC
GATTGTGGCCTCCCAGATCAAGGAAGGCGAACCGACAAAGCTGTCGCTCGCCCTGGAAGACGGCGAAGTTCGCACCGTGA
CGCTTGCGCCGGCCTTGACGGCTTCGCTACTCGAAGTGCTGCGGCTTGTCTCGAGCGGTCGCGGGTTTCGGATGATCCCC
GTCGAGTCAGAGCTGACCACGCAGCAGGCGGCGGACCTTCTCAATGTGTCCCGGCCGTTCCTAGTGAAGCTTCTCGAGGA
AGGCGAGATTCCCTTTGCGAAGACCGGCCGTCATCGCCGGGTTCGTGCCGACGACCTCTTTGCCTACAAGGAGAAGCGTG
ACGCGTCTCGCTCTGATGCTTTGAGTGACCTTGCTGCAATGGATGCGGAAGAAGGTCTTGTATGA
ATGAACGCCCTCAGAAAAGAGGCGTTCTTTGATCGTTTGCCCGACGAGGTAGAGATCAAGAACGCCGAACAACTCAGAAC
GATTGTGGCCTCCCAGATCAAGGAAGGCGAACCGACAAAGCTGTCGCTCGCCCTGGAAGACGGCGAAGTTCGCACCGTGA
CGCTTGCGCCGGCCTTGACGGCTTCGCTACTCGAAGTGCTGCGGCTTGTCTCGAGCGGTCGCGGGTTTCGGATGATCCCC
GTCGAGTCAGAGCTGACCACGCAGCAGGCGGCGGACCTTCTCAATGTGTCCCGGCCGTTCCTAGTGAAGCTTCTCGAGGA
AGGCGAGATTCCCTTTGCGAAGACCGGCCGTCATCGCCGGGTTCGTGCCGACGACCTCTTTGCCTACAAGGAGAAGCGTG
ACGCGTCTCGCTCTGATGCTTTGAGTGACCTTGCTGCAATGGATGCGGAAGAAGGTCTTGTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2P8K6F2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GJ93 |