Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3696992..3697664 Replicon chromosome
Accession NC_008800
Organism Yersinia enterocolitica subsp. enterocolitica 8081

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U7FIQ4
Locus tag YE_RS16955 Protein ID WP_005166047.1
Coordinates 3696992..3697417 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U7FJE4
Locus tag YE_RS16960 Protein ID WP_004390965.1
Coordinates 3697398..3697664 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE_RS16935 (YE3381) 3692763..3693284 + 522 WP_011817021.1 flavodoxin FldB -
YE_RS16940 (YE3382) 3693343..3694764 - 1422 WP_011817022.1 cell envelope integrity protein CreD -
YE_RS16945 (YE3383) 3694856..3696283 - 1428 WP_011817023.1 two-component system sensor histidine kinase CreC -
YE_RS16950 (YE3384) 3696294..3696992 - 699 WP_011817024.1 two-component system response regulator CreB -
YE_RS16955 (YE3385) 3696992..3697417 - 426 WP_005166047.1 protein YgfX Toxin
YE_RS16960 (YE3386) 3697398..3697664 - 267 WP_004390965.1 FAD assembly factor SdhE Antitoxin
YE_RS16965 (YE3387) 3698059..3699051 + 993 WP_011817025.1 tRNA-modifying protein YgfZ -
YE_RS16970 (YE3388) 3699105..3699788 - 684 WP_005173485.1 hemolysin III family protein -
YE_RS16975 (YE3389) 3700019..3700621 + 603 WP_011817027.1 HD domain-containing protein -
YE_RS16980 3700634..3700768 - 135 Protein_3289 SDR family oxidoreductase -
YE_RS16985 (YE3390) 3700807..3701244 - 438 WP_005173494.1 lipocalin-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16425.21 Da        Isoelectric Point: 9.8217

>T21945 WP_005166047.1 NC_008800:c3697417-3696992 [Yersinia enterocolitica subsp. enterocolitica 8081]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Download         Length: 426 bp

>T21945 NC_008800:c3697417-3696992 [Yersinia enterocolitica subsp. enterocolitica 8081]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTGACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCGCTGTGGTTGGTGTTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.01 Da        Isoelectric Point: 5.1405

>AT21945 WP_004390965.1 NC_008800:c3697664-3697398 [Yersinia enterocolitica subsp. enterocolitica 8081]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT21945 NC_008800:c3697664-3697398 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGCTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FIQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJE4

References