Detailed information of TA system TA219449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2702467..2704055
• Replicon: chromosome
• Accession: NZ_CP084818
• Organism: Klebsiella quasipneumoniae subsp. quasipneumoniae strain 18A069

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LGM21_RS13315
• Protein ID: WP_032452828.1
• Coordinates: 2702467..2703789 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2N4W0X3
• Locus tag: LGM21_RS13320
• Protein ID: WP_023289667.1
• Coordinates: 2703789..2704055 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM21_RS13290 (2697512)	2697512..2699167	-	1656	WP_023289671.1	EAL domain-containing protein	-
LGM21_RS13295 (2699465)	2699465..2699713	+	249	WP_004205912.1	hypothetical protein	-
LGM21_RS13300 (2700005)	2700005..2700223	+	219	WP_002904808.1	ParD-like family protein	-
LGM21_RS13305 (2700204)	2700204..2700986	+	783	WP_032452830.1	type I methionyl aminopeptidase	-
LGM21_RS13310 (2701158)	2701158..2702450	+	1293	WP_032452829.1	glycoside hydrolase family 10 protein	-
LGM21_RS13315 (2702467)	2702467..2703789	-	1323	WP_032452828.1	type II toxin-antitoxin system HipA family toxin	Toxin
LGM21_RS13320 (2703789)	2703789..2704055	-	267	WP_023289667.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LGM21_RS13325 (2704805)	2704805..2705131	-	327	WP_032452826.1	hydroxyisourate hydrolase	-
LGM21_RS13330 (2705128)	2705128..2705628	-	501	WP_032452825.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LGM21_RS13335 (2705606)	2705606..2706985	-	1380	WP_032452824.1	nucleobase:cation symporter-2 family protein	-
LGM21_RS13340 (2707331)	2707331..2708485	+	1155	WP_032452823.1	FAD-dependent urate hydroxylase HpxO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49202.53 Da
• Isoelectric Point: 8.9165

>T219449 WP_032452828.1 NZ_CP084818:c2703789-2702467 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDDEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEARLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPRDQMLAILDEFADRVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAR

Nucleotide

• Length: 1323 bp

>T219449 NZ_CP116426:100842-101237 [Sulfitobacter faviae]
ATGAGCGTTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGACGACGGCCCAAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTTCTAAACGAGTCACTGGTGAACTGCCGCCGCAAAGCTGGCCTCGGTT
GGGAGGAAGCAGCGGCCTTTCTCGAAGGCGTGCGCGCCTTGTGTCCCGTCGAAGATCTCACCGTGCAGACCCATGACGTC
GGCCGCGCTTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCGATGATCGTGGCCAGCGCTTTGGTTGCGGGGTGTAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAGCTTCGCATCGTCAACCCCTTTGCATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9891.25 Da
• Isoelectric Point: 7.3163

>AT219449 WP_023289667.1 NZ_CP084818:c2704055-2703789 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MHSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETATAP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT219449 NZ_CP116426:100625-100852 [Sulfitobacter faviae]
ATGCAGGTCGCAAAATGGGGTAACTCGCTGGCCGTCCGTTTGCCCGCGGAGCTCGTCCGAGAGCTTGGTCTCAAGGAGGG
TGATCAGATCGACCTGGTCAAGGACGACGGTCGGGTCAGAGTCCGTCGCCTTGCTCGTGCGGATGAGGTACTTACCGGCC
TGCGCCGCTTCCGGGGCAAGTTGTCCGCAGCAGAACGTCTGAGCCGCGACGACGCACATGAGCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A2N4W0X3