Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812576..813233 Replicon chromosome
Accession NZ_CP084818
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain 18A069

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag LGM21_RS04080 Protein ID WP_023290968.1
Coordinates 812823..813233 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM21_RS04075 Protein ID WP_002916312.1
Coordinates 812576..812842 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM21_RS04050 (807726) 807726..809159 - 1434 WP_032454034.1 6-phospho-beta-glucosidase -
LGM21_RS04055 (809278) 809278..810006 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
LGM21_RS04060 (810057) 810057..810368 + 312 WP_032454032.1 N(4)-acetylcytidine aminohydrolase -
LGM21_RS04065 (810532) 810532..811191 + 660 WP_008806429.1 hemolysin III family protein -
LGM21_RS04070 (811347) 811347..812330 - 984 WP_065805876.1 tRNA-modifying protein YgfZ -
LGM21_RS04075 (812576) 812576..812842 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM21_RS04080 (812823) 812823..813233 + 411 WP_023290968.1 protein YgfX Toxin
LGM21_RS04085 (813240) 813240..813761 - 522 WP_004205324.1 flavodoxin FldB -
LGM21_RS04090 (813862) 813862..814758 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM21_RS04095 (814781) 814781..815494 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM21_RS04100 (815500) 815500..817233 + 1734 WP_032454029.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T219440 WP_023290968.1 NZ_CP084818:812823-813233 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219440 NZ_CP116411:3545401-3545619 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219440 WP_002916312.1 NZ_CP084818:812576-812842 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219440 NZ_CP116411:3545001-3545375 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References