Detailed information of TA system TA021944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3386958..3387575
• Replicon: chromosome
• Accession: NC_008800
• Organism: Yersinia enterocolitica subsp. enterocolitica 8081

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: Q66DR5
• Locus tag: YE_RS15630
• Protein ID: WP_002208622.1
• Coordinates: 3387372..3387575 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: Q6TU35
• Locus tag: YE_RS15625
• Protein ID: WP_005167670.1
• Coordinates: 3386958..3387326 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE_RS15595 (YE3107)	3382624..3382884	+	261	WP_005163438.1	type B 50S ribosomal protein L31	-
YE_RS15600 (YE3108)	3382900..3383043	+	144	WP_002208618.1	type B 50S ribosomal protein L36	-
YE_RS15605 (YE3109)	3383171..3384049	-	879	WP_011816885.1	metal ABC transporter substrate-binding protein	-
YE_RS15610 (YE3110)	3384095..3384952	-	858	WP_011816886.1	metal ABC transporter permease	-
YE_RS15615 (YE3111)	3384949..3385677	-	729	WP_011816887.1	ABC transporter ATP-binding protein	-
YE_RS15620 (YE3113)	3386447..3386800	+	354	WP_011816888.1	hypothetical protein	-
YE_RS15625 (YE3114)	3386958..3387326	+	369	WP_005167670.1	Hha toxicity modulator TomB	Antitoxin
YE_RS15630 (YE3115)	3387372..3387575	+	204	WP_002208622.1	expression modulating protein YmoA	Toxin
YE_RS15640 (YE3116)	3388421..3388726	+	306	WP_032909388.1	MGMT family protein	-
YE_RS15645 (YE3117)	3388778..3389308	-	531	WP_005167665.1	lipoprotein	-
YE_RS15650 (YE3118)	3389566..3390429	+	864	WP_005167662.1	acyl-CoA thioesterase II	-
YE_RS15655 (YE3119)	3390729..3392018	-	1290	WP_005167660.1	ammonium transporter AmtB	-
YE_RS15660 (YE3120)	3392058..3392396	-	339	WP_002208627.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8063.31 Da
• Isoelectric Point: 6.4573

>T21944 WP_002208622.1 NC_008800:3387372-3387575 [Yersinia enterocolitica subsp. enterocolitica 8081]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Nucleotide

• Length: 204 bp

>T21944 NC_008800:3387372-3387575 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14134.86 Da
• Isoelectric Point: 4.4085

>AT21944 WP_005167670.1 NC_008800:3386958-3387326 [Yersinia enterocolitica subsp. enterocolitica 8081]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Nucleotide

• Length: 369 bp

>AT21944 NC_008800:3386958-3387326 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGCGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACCAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAA

Structures

Toxin

• PDB: 2K5S

Antitoxin

• AlphaFold DB: A0A8B6L1C1