Detailed information of TA system TA219434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4585889..4586360
• Replicon: chromosome
• Accession: NZ_CP084806
• Organism: Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB1124

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGM22_RS22515
• Protein ID: WP_023291758.1
• Coordinates: 4585889..4586128 (-)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: LGM22_RS22520
• Protein ID: WP_023291757.1
• Coordinates: 4586118..4586360 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM22_RS22505 (4582846)	4582846..4584984	+	2139	WP_136069752.1	anaerobic ribonucleoside-triphosphate reductase	-
LGM22_RS22510 (4585376)	4585376..4585840	+	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LGM22_RS22515 (4585889)	4585889..4586128	-	240	WP_023291758.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGM22_RS22520 (4586118)	4586118..4586360	-	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LGM22_RS22525 (4586438)	4586438..4588348	-	1911	WP_044525201.1	PRD domain-containing protein	-
LGM22_RS22530 (4588371)	4588371..4589522	-	1152	WP_023291755.1	lactonase family protein	-
LGM22_RS22535 (4589589)	4589589..4590329	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-79)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9162.72 Da
• Isoelectric Point: 10.1315

>T219434 WP_023291758.1 NZ_CP084806:c4586128-4585889 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIG

Nucleotide

• Length: 240 bp

>T219434 NZ_CP116411:928815-929222 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT219434 WP_023291757.1 NZ_CP084806:c4586360-4586118 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT219434 NZ_CP116411:928568-928834 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86