Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 1521085..1522082 | Replicon | chromosome |
| Accession | NZ_CP084806 | ||
| Organism | Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB1124 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | LGM22_RS07560 | Protein ID | WP_229531768.1 |
| Coordinates | 1521528..1522082 (-) | Length | 185 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | LGM22_RS07555 | Protein ID | WP_136069981.1 |
| Coordinates | 1521085..1521531 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM22_RS07530 (1516320) | 1516320..1517318 | + | 999 | WP_008804028.1 | galactose/glucose ABC transporter substrate-binding protein MglB | - |
| LGM22_RS07535 (1517437) | 1517437..1517697 | + | 261 | Protein_1466 | ATP-binding cassette domain-containing protein | - |
| LGM22_RS07540 (1517777) | 1517777..1518694 | + | 918 | WP_028016400.1 | IS5-like element ISEc35 family transposase | - |
| LGM22_RS07545 (1518752) | 1518752..1520017 | + | 1266 | Protein_1468 | galactose/methyl galactoside ABC transporter ATP-binding protein MglA | - |
| LGM22_RS07550 (1520033) | 1520033..1521043 | + | 1011 | WP_002912871.1 | galactose/methyl galactoside ABC transporter permease MglC | - |
| LGM22_RS07555 (1521085) | 1521085..1521531 | - | 447 | WP_136069981.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| LGM22_RS07560 (1521528) | 1521528..1522082 | - | 555 | WP_229531768.1 | HipA domain-containing protein | Toxin |
| LGM22_RS07565 (1522111) | 1522111..1522632 | - | 522 | WP_226683541.1 | phosphatidylinositol kinase | - |
| LGM22_RS07570 (1522747) | 1522747..1523478 | - | 732 | WP_008804033.1 | outer membrane permeability protein SanA | - |
| LGM22_RS07575 (1523753) | 1523753..1524637 | - | 885 | WP_136069982.1 | cytidine deaminase | - |
| LGM22_RS07580 (1524766) | 1524766..1525461 | - | 696 | WP_008804035.1 | CidB/LrgB family autolysis modulator | - |
| LGM22_RS07585 (1525451) | 1525451..1525855 | - | 405 | WP_004201620.1 | CidA/LrgA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | galF / cpsACP / wzi / wza / gnd / manC / manB / wbtL / ugd / wbtL | 1502140..1707256 | 205116 | |
| - | flank | IS/Tn | - | - | 1517777..1518694 | 917 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 185 a.a. Molecular weight: 20710.03 Da Isoelectric Point: 5.7891
>T219423 WP_229531768.1 NZ_CP084806:c1522082-1521528 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL
Download Length: 555 bp
>T219423 NZ_CP116409:3865530-3865748 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16366.03 Da Isoelectric Point: 10.5417
>AT219423 WP_136069981.1 NZ_CP084806:c1521531-1521085 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MKTLNKKETEIQNTLARLRADNPPSLPAAGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK
MKTLNKKETEIQNTLARLRADNPPSLPAAGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK
Download Length: 447 bp
>AT219423 NZ_CP116409:3865130-3865504 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
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