Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 774929..775586 Replicon chromosome
Accession NZ_CP084806
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB1124

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag LGM22_RS03870 Protein ID WP_023290968.1
Coordinates 775176..775586 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM22_RS03865 Protein ID WP_002916312.1
Coordinates 774929..775195 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM22_RS03840 (770097) 770097..771530 - 1434 WP_086074972.1 6-phospho-beta-glucosidase BglA -
LGM22_RS03845 (771649) 771649..772377 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
LGM22_RS03850 (772428) 772428..772739 + 312 WP_086074973.1 N(4)-acetylcytidine aminohydrolase -
LGM22_RS03855 (772903) 772903..773565 + 663 WP_065883827.1 hemolysin III family protein -
LGM22_RS03860 (773700) 773700..774683 - 984 WP_086074974.1 tRNA-modifying protein YgfZ -
LGM22_RS03865 (774929) 774929..775195 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM22_RS03870 (775176) 775176..775586 + 411 WP_023290968.1 protein YgfX Toxin
LGM22_RS03875 (775593) 775593..776114 - 522 WP_004205324.1 flavodoxin FldB -
LGM22_RS03880 (776215) 776215..777111 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM22_RS03885 (777134) 777134..777847 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM22_RS03890 (777853) 777853..779586 + 1734 WP_065883824.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T219422 WP_023290968.1 NZ_CP084806:775176-775586 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219422 NZ_CP116409:3105417-3105524 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219422 WP_002916312.1 NZ_CP084806:774929-775195 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219422 NZ_CP116409:c3105370-3105304 [Escherichia coli]
TGTCTTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References