219420

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 311465..311987 Replicon plasmid pKqq_SB98_1
Accession NZ_CP084804
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB98

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag LGM23_RS27610 Protein ID WP_004181778.1
Coordinates 311465..311749 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag LGM23_RS27615 Protein ID WP_004181777.1
Coordinates 311739..311987 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM23_RS27575 (LGM23_27575) 307103..307447 + 345 WP_223811496.1 hypothetical protein -
LGM23_RS27580 (LGM23_27580) 307444..307815 + 372 WP_040209644.1 hypothetical protein -
LGM23_RS27585 (LGM23_27585) 307860..309047 - 1188 WP_040209642.1 RNA-guided endonuclease TnpB family protein -
LGM23_RS27590 (LGM23_27590) 309083..309511 + 429 WP_077257669.1 IS200/IS605 family transposase -
LGM23_RS27595 (LGM23_27595) 309590..309814 + 225 Protein_289 transposase -
LGM23_RS27600 (LGM23_27600) 310085..311311 - 1227 WP_040209639.1 RNA-guided endonuclease TnpB family protein -
LGM23_RS27605 (LGM23_27605) 311347..311448 + 102 Protein_291 IS200/IS605 family transposase -
LGM23_RS27610 (LGM23_27610) 311465..311749 - 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM23_RS27615 (LGM23_27615) 311739..311987 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LGM23_RS27620 (LGM23_27620) 312278..314077 + 1800 WP_004181776.1 ATP-dependent helicase -
LGM23_RS27625 (LGM23_27625) 314411..315397 + 987 WP_025368599.1 hypothetical protein -
LGM23_RS27630 (LGM23_27630) 315542..315895 + 354 WP_004181774.1 hypothetical protein -
LGM23_RS27635 (LGM23_27635) 315957..316778 + 822 WP_004181772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..332984 332984


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T219420 WP_004181778.1 NZ_CP084804:c311749-311465 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T219420 NZ_CP116409:2455630-2455733 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT219420 WP_004181777.1 NZ_CP084804:c311987-311739 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT219420 NZ_CP116409:c2455771-2455500 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References